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Reep4 receptor accessory protein 4 [ Mus musculus (house mouse) ]

Gene ID: 72549, updated on 27-Nov-2024

Summary

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Official Symbol
Reep4provided by MGI
Official Full Name
receptor accessory protein 4provided by MGI
Primary source
MGI:MGI:1919799
See related
Ensembl:ENSMUSG00000033589 AllianceGenome:MGI:1919799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700029E10Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization and mitotic nuclear membrane reassembly. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Is expressed in vibrissa. Orthologous to human REEP4 (receptor accessory protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 61.3), thymus adult (RPKM 48.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Reep4 in Genome Data Viewer
Location:
14 D2; 14 36.32 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70782666..70786375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70545223..70548935)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene surfactant associated protein C Neighboring gene leucine-rich repeat LGI family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E7333 Neighboring gene STARR-positive B cell enhancer ABC_E1901 Neighboring gene lysine demethylase and nuclear receptor corepressor Neighboring gene predicted gene, 53866

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic nuclear membrane reassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic nuclear membrane reassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor expression-enhancing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180588.2 → NP_850919.1  receptor expression-enhancing protein 4

    See identical proteins and their annotated locations for NP_850919.1

    Status: VALIDATED

    Source sequence(s)
    AC122268, BC033929, BF464286
    Consensus CDS
    CCDS27256.1
    UniProtKB/Swiss-Prot
    Q8K072
    Related
    ENSMUSP00000040162.4, ENSMUST00000047218.5
    Conserved Domains (2) summary
    PRK11675
    Location:211 → 243
    PRK11675; LexA regulated protein; Provisional
    pfam03134
    Location:7 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70782666..70786375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519598.5 → XP_006519661.1  receptor expression-enhancing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A2I3BQJ3
    Related
    ENSMUSP00000154206.2, ENSMUST00000226563.2
    Conserved Domains (2) summary
    PRK11675
    Location:247 → 279
    PRK11675; LexA regulated protein; Provisional
    pfam03134
    Location:19 → 130
    TB2_DP1_HVA22; TB2/DP1, HVA22 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K072.1 GenPept UniProtKB/Swiss-Prot:Q8K072

Gene LinkOut

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