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C1qtnf6 C1q and tumor necrosis factor related protein 6 [ Mus musculus (house mouse) ]

Gene ID: 72709, updated on 4-Jan-2025

Summary

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Official Symbol
C1qtnf6provided by MGI
Official Full Name
C1q and tumor necrosis factor related protein 6provided by MGI
Primary source
MGI:MGI:1919959
See related
Ensembl:ENSMUSG00000022440 AllianceGenome:MGI:1919959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adiq; CTRP6; 2810036M19Rik
Summary
Enables identical protein binding activity. Located in extracellular space. Part of protein-containing complex. Orthologous to human C1QTNF6 (C1q and TNF related 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in ovary adult (RPKM 62.8), limb E14.5 (RPKM 28.7) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See C1qtnf6 in Genome Data Viewer
Location:
15 E1; 15 37.55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78407546..78416370, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78523346..78532170, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 6 Neighboring gene STARR-positive B cell enhancer ABC_E8598 Neighboring gene STARR-seq mESC enhancer starr_39146 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78306098-78306207 Neighboring gene interleukin 2 receptor, beta chain Neighboring gene STARR-positive B cell enhancer ABC_E4139 Neighboring gene STARR-seq mESC enhancer starr_39149 Neighboring gene somatostatin receptor 3 Neighboring gene L antigen family, member 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation. Xu C, et al. J Biol Chem, 2024 Jan. PMID 38103643, Free PMC Article
  2. CTRP6 suppresses neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury through inactivation of ERK pathway. Li J, et al. Allergol Immunopathol (Madr), 2022. PMID 36335445
  3. CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt). Liu Z, et al. Bioengineered, 2021 Dec. PMID 34516328, Free PMC Article
  4. C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury. Zheng WF, et al. J Cell Biochem, 2019 Jun. PMID 30719766
  5. Lentivirus-mediated CTRP6 silencing ameliorates diet-induced obesity in mice. Wu W, et al. Exp Cell Res, 2018 Jun 1. PMID 29366805

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway in intrauterine adhesiondagger.
    Title: CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway in intrauterine adhesion†.
  2. CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation.
    Title: CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation.
  3. CTRP6 suppresses neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury through inactivation of ERK pathway.
    Title: CTRP6 suppresses neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury through inactivation of ERK pathway.
  4. CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt).
    Title: CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt).
  5. CTRP6 rapidly responds to acute nutritional changes, regulating adipose tissue expansion and inflammation in mice.
    Title: CTRP6 rapidly responds to acute nutritional changes, regulating adipose tissue expansion and inflammation in mice.
  6. Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation.
    Title: Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation.
  7. CTRP6 protected the heart from doxorubicin cardiotoxicity and improved cardiac function via activation of the AKT signaling pathway.
    Title: C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury.
  8. CTRP6 knockdown protects against diet-induced obesity and promotes brown adipogenesis in mice.
    Title: Lentivirus-mediated CTRP6 silencing ameliorates diet-induced obesity in mice.
  9. The results establish CTRP6 as a novel metabolic/immune regulator linking obesity to adipose tissue inflammation and insulin resistance.
    Title: C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance.
  10. CTRP6 knockdown down-regulated the levels of lipogenic genes and phosphorylated Erk1/2 (p-Erk1/2) in the early lipogenic stage, whereas up-regulated p-Erk1/2 in the terminal differentiation in skeletal myoblasts.
    Title: Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPARγ signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 6
Names
adiponectin q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204152.1 → NP_001191081.1  complement C1q tumor necrosis factor-related protein 6 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI853798, AK012868, AL590144
    Consensus CDS
    CCDS88801.1
    UniProtKB/TrEMBL
    A0A2R8W6P9
    Related
    ENSMUSP00000155221.2, ENSMUST00000229185.2

  2. NM_001204153.1 → NP_001191082.1  complement C1q tumor necrosis factor-related protein 6 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001191082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590144
    Related
    ENSMUST00000147093.2

  3. NM_028331.5 → NP_082607.3  complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_082607.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI853798, AK012868, AL590144, DQ002399
    Consensus CDS
    CCDS37134.1
    UniProtKB/Swiss-Prot
    Q6IR41, Q8BKR0
    UniProtKB/TrEMBL
    A0A3B0IP29
    Related
    ENSMUSP00000023075.9, ENSMUST00000023075.9
    Conserved Domains (2) summary
    pfam01391
    Location:83 → 122
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:131 → 259
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78407546..78416370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521455.4 → XP_006521518.1  complement C1q tumor necrosis factor-related protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006521518.1

    Conserved Domains (2) summary
    pfam01391
    Location:79 → 118
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:127 → 255
    C1q; C1q domain

  2. XM_006521452.5 → XP_006521515.1  complement C1q tumor necrosis factor-related protein 6 isoform X2

    Conserved Domains (2) summary
    pfam01391
    Location:111 → 150
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:159 → 287
    C1q; C1q domain

  3. XM_036159608.1 → XP_036015501.1  complement C1q tumor necrosis factor-related protein 6 isoform X1

    Conserved Domains (2) summary
    pfam00386
    Location:175 → 303
    C1q; C1q domain
    pfam01391
    Location:127 → 166
    Collagen; Collagen triple helix repeat (20 copies)

  4. XM_006521453.4 → XP_006521516.1  complement C1q tumor necrosis factor-related protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006521516.1

    Conserved Domains (2) summary
    pfam01391
    Location:79 → 118
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:127 → 255
    C1q; C1q domain

  5. XM_036159609.1 → XP_036015502.1  complement C1q tumor necrosis factor-related protein 6 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IR41.1 GenPept UniProtKB/Swiss-Prot:Q6IR41

Gene LinkOut

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