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TTK TTK protein kinase [ Homo sapiens (human) ]

Gene ID: 7272, updated on 27-Nov-2024

Summary

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Official Symbol
TTKprovided by HGNC
Official Full Name
TTK protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:12401
See related
Ensembl:ENSG00000112742 MIM:604092; AllianceGenome:HGNC:12401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESK; PYT; CT96; MPH1; MPS1; MPS1L1
Summary
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Expression
Biased expression in testis (RPKM 13.6), bone marrow (RPKM 6.1) and 10 other tissues See more
Orthologs
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Genomic context

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See TTK in Genome Data Viewer
Location:
6q14.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (80004649..80042527)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (81213044..81250924)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (80714366..80752244)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901351 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 63 Neighboring gene ribosomal protein L35a pseudogene 18 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:80702927-80703569 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:80713403-80714277 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene adenylate kinase 4 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1. Hennrich ML, et al. J Proteome Res, 2013 May 3. PMID 23510141
  2. Expression and function analysis of mitotic checkpoint genes identifies TTK as a potential therapeutic target for human hepatocellular carcinoma. Liang XD, et al. PLoS One, 2014. PMID 24905462, Free PMC Article
  3. Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis. Miao R, et al. J Hepatol, 2014 Oct. PMID 24859455
  4. Identification of the hot spot residues for pyridine derivative inhibitor CCT251455 and ATP substrate binding on monopolar spindle 1 (MPS1) kinase by molecular dynamic simulation. Chen K, et al. J Biomol Struct Dyn, 2019 Feb. PMID 29380674
  5. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Slee RB, et al. Mol Cancer Ther, 2014 Feb. PMID 24282275, Free PMC Article

See all (220) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of TTK in Colorectal Cancer.
    Title: CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of TTK in Colorectal Cancer.
  2. TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer.
    Title: TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer.
  3. TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma.
    Title: TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma.
  4. TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion.
    Title: TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion.
  5. Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma.
    Title: Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma.
  6. Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis.
    Title: Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis.
  7. Frequent expression of a novel cancer testis antigen, protein kinase human monopolar spindle 1 (hMps1/TTK) in human urinary bladder transitional cell carcinoma.
    Title: Frequent expression of a novel cancer testis antigen, protein kinase human monopolar spindle 1 (hMps1/TTK) in human urinary bladder transitional cell carcinoma.
  8. Overexpressed MPS-1 contributes to endometrioma development through the NF-kappaB signaling pathway.
    Title: Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway.
  9. TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer.
    Title: TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer.
  10. CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression.
    Title: CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression.
Submit: New GeneRIF Correction See all GeneRIFs (125)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables kinetochore binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female meiosis chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of SMAD protein signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to meiotic spindle midzone IEA
Inferred from Electronic Annotation
more info
  
involved_in repair of mitotic kinetochore microtubule attachment defect IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spindle organization TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein kinase TTK
Names
cancer/testis antigen 96
monopolar spindle 1 kinase
monopolar spindle 1-like 1
phosphotyrosine picked threonine kinase
phosphotyrosine picked threonine-protein kinase
NP_001160163.1
NP_003309.2
XP_011534401.1
XP_011534402.1
XP_016866731.1
XP_054212283.1
XP_054212284.1
XP_054212285.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166691.2 → NP_001160163.1  dual specificity protein kinase TTK isoform 2

    See identical proteins and their annotated locations for NP_001160163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' UTR and in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK292460, AL133475, AU154042
    Consensus CDS
    CCDS55040.1
    UniProtKB/Swiss-Prot
    P33981
    Related
    ENSP00000230510.3, ENST00000230510.7
    Conserved Domains (2) summary
    cd14131
    Location:522 → 790
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:524 → 790
    Pkinase; Protein kinase domain

  2. NM_003318.5 → NP_003309.2  dual specificity protein kinase TTK isoform 1

    See identical proteins and their annotated locations for NP_003309.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK315696, AU154042, DA853919
    Consensus CDS
    CCDS4993.1
    UniProtKB/Swiss-Prot
    A8K8U5, B2RDW2, E1P543, P33981, Q15272, Q5TCS0, Q9BW51, Q9NTM0
    Related
    ENSP00000358813.2, ENST00000369798.7
    Conserved Domains (1) summary
    cd14131
    Location:523 → 791
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    80004649..80042527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536099.4 → XP_011534401.1  dual specificity protein kinase TTK isoform X1

    See identical proteins and their annotated locations for XP_011534401.1

    UniProtKB/Swiss-Prot
    A8K8U5, B2RDW2, E1P543, P33981, Q15272, Q5TCS0, Q9BW51, Q9NTM0
    Conserved Domains (1) summary
    cd14131
    Location:523 → 791
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

  2. XM_011536100.4 → XP_011534402.1  dual specificity protein kinase TTK isoform X2

    See identical proteins and their annotated locations for XP_011534402.1

    UniProtKB/Swiss-Prot
    P33981
    Related
    ENSP00000422936.1, ENST00000509894.5
    Conserved Domains (2) summary
    cd14131
    Location:522 → 790
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:524 → 790
    Pkinase; Protein kinase domain

  3. XM_017011242.3 → XP_016866731.1  dual specificity protein kinase TTK isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    81213044..81250924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356308.1 → XP_054212283.1  dual specificity protein kinase TTK isoform X1

    UniProtKB/Swiss-Prot
    A8K8U5, B2RDW2, E1P543, P33981, Q15272, Q5TCS0, Q9BW51, Q9NTM0

  2. XM_054356309.1 → XP_054212284.1  dual specificity protein kinase TTK isoform X2

  3. XM_054356310.1 → XP_054212285.1  dual specificity protein kinase TTK isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33981.2 GenPept UniProtKB/Swiss-Prot:P33981

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