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NUTM2D NUT family member 2D [ Homo sapiens (human) ]

Gene ID: 728130, updated on 27-Nov-2024

Summary

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Official Symbol
NUTM2Dprovided by HGNC
Official Full Name
NUT family member 2Dprovided by HGNC
Primary source
HGNC:HGNC:23447
See related
Ensembl:ENSG00000214562 AllianceGenome:HGNC:23447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM22D
Expression
Ubiquitous expression in testis (RPKM 1.6), brain (RPKM 1.5) and 25 other tissues See more
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Genomic context

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See NUTM2D in Genome Data Viewer
Location:
10q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (87357744..87370695)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (88241352..88254302)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89117501..89130452)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88987203-88987977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88988752-88989526 Neighboring gene NUT family member 2A Neighboring gene NUTM2A antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:89102067-89102674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2581 Neighboring gene long intergenic non-protein coding RNA 863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:89114408-89114914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:89114915-89115421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:89119641-89120142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:89142841-89143342 Neighboring gene nuclear pore associated protein 1 pseudogene 3 Neighboring gene cathepsin L pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article
  2. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
  4. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA2020

General protein information

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Preferred Names
NUT family member 2D
Names
NUT family member 2A pseudogene
family with sequence similarity 22, member D
protein FAM22D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009610.2 → NP_001009610.1  NUT family member 2D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645612
    UniProtKB/TrEMBL
    A0A075B6P9, A0A0A0MRQ8
    Related
    ENSP00000396080.1, ENST00000412718.3
    Conserved Domains (1) summary
    pfam12881
    Location:64 → 545
    NUT; NUT protein

  2. NM_001382304.1 → NP_001369233.1  NUT family member 2D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645612
    Consensus CDS
    CCDS91292.1
    UniProtKB/Swiss-Prot
    A6NGV9, Q5VT03
    Related
    ENSP00000371116.1, ENST00000381697.7
    Conserved Domains (1) summary
    pfam12881
    Location:64 → 803
    NUT; NUT protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    87357744..87370695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    88241352..88254302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VT03.2 GenPept UniProtKB/Swiss-Prot:Q5VT03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials