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NPIPB8 nuclear pore complex interacting protein family member B8 [ Homo sapiens (human) ]

Gene ID: 728734, updated on 10-Dec-2024

Summary

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Official Symbol
NPIPB8provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B8provided by HGNC
Primary source
HGNC:HGNC:37490
See related
Ensembl:ENSG00000255524 AllianceGenome:HGNC:37490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 22.6), skin (RPKM 8.3) and 23 other tissues See more
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Genomic context

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See NPIPB8 in Genome Data Viewer
Location:
16p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28637891..28658744)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28928825..28939457)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28649212..28670065)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610237-28610771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610772-28611305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28612139-28612653 Neighboring gene sulfotransferase family 1A member 2 Neighboring gene uncharacterized LOC107984835 Neighboring gene uncharacterized LOC124903674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28623750-28624250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28624498-28625048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28625049-28625598 Neighboring gene sulfotransferase family 1A member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28626587-28627161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28677654-28678567 Neighboring gene small nucleolar RNA U13 Neighboring gene eukaryotic translation initiation factor 3 subunit C Neighboring gene cell division cycle 37 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

General protein information

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Preferred Names
nuclear pore complex-interacting protein family member B8
Names
Nuclear pore complex-interacting protein family member B8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310136.2 → NP_001297065.1  nuclear pore complex-interacting protein family member B8

    See identical proteins and their annotated locations for NP_001297065.1

    Status: VALIDATED

    Source sequence(s)
    AC020765, AC145285
    Consensus CDS
    CCDS81963.1
    UniProtKB/Swiss-Prot
    E9PQR5
    UniProtKB/TrEMBL
    B2RXF8
    Related
    ENSP00000507410.1, ENST00000683297.1
    Conserved Domains (2) summary
    pfam06409
    Location:48 → 301
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_001385922.1 → NP_001372851.1  nuclear pore complex-interacting protein family member B8

    Status: VALIDATED

    Source sequence(s)
    AC020765, AC145285
    Consensus CDS
    CCDS81963.1
    UniProtKB/Swiss-Prot
    E9PQR5
    UniProtKB/TrEMBL
    B2RXF8
    Related
    ENSP00000434399.1, ENST00000529716.5
    Conserved Domains (2) summary
    pfam06409
    Location:48 → 301
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28637891..28658744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434559.1 → XP_047290515.1  nuclear pore complex-interacting protein family member B8 isoform X1

    UniProtKB/TrEMBL
    B2RXF8

  2. XM_047434565.1 → XP_047290521.1  nuclear pore complex-interacting protein family member B8 isoform X4

    UniProtKB/TrEMBL
    B2RXF8

  3. XM_017023622.2 → XP_016879111.1  nuclear pore complex-interacting protein family member B8 isoform X1

    UniProtKB/TrEMBL
    B2RXF8

  4. XM_047434566.1 → XP_047290522.1  nuclear pore complex-interacting protein family member B8 isoform X5

    UniProtKB/TrEMBL
    B2RXF8

  5. XM_047434560.1 → XP_047290516.1  nuclear pore complex-interacting protein family member B8 isoform X1

    UniProtKB/TrEMBL
    B2RXF8

  6. XM_047434561.1 → XP_047290517.1  nuclear pore complex-interacting protein family member B8 isoform X2

    UniProtKB/TrEMBL
    I3L0I5

  7. XM_017023625.2 → XP_016879114.1  nuclear pore complex-interacting protein family member B8 isoform X7

    UniProtKB/TrEMBL
    I3L0I5

  8. XM_047434562.1 → XP_047290518.1  nuclear pore complex-interacting protein family member B8 isoform X3

    UniProtKB/TrEMBL
    I3L0I5

  9. XM_047434563.1 → XP_047290519.1  nuclear pore complex-interacting protein family member B8 isoform X3

    UniProtKB/TrEMBL
    I3L0I5

  10. XM_047434568.1 → XP_047290524.1  nuclear pore complex-interacting protein family member B8 isoform X8

    UniProtKB/TrEMBL
    I3L0I5

  11. XM_047434569.1 → XP_047290525.1  nuclear pore complex-interacting protein family member B8 isoform X9

    UniProtKB/TrEMBL
    A0A494C1T1

  12. XM_047434570.1 → XP_047290526.1  nuclear pore complex-interacting protein family member B8 isoform X10

    UniProtKB/TrEMBL
    A0A494C1T1

  13. XM_047434564.1 → XP_047290520.1  nuclear pore complex-interacting protein family member B8 isoform X3

    UniProtKB/TrEMBL
    I3L0I5

  14. XM_047434567.1 → XP_047290523.1  nuclear pore complex-interacting protein family member B8 isoform X6

    UniProtKB/TrEMBL
    I3L0I5

  15. XM_047434572.1 → XP_047290528.1  nuclear pore complex-interacting protein family member B8 isoform X12

  16. XM_047434571.1 → XP_047290527.1  nuclear pore complex-interacting protein family member B8 isoform X11

  17. XM_047434573.1 → XP_047290529.1  nuclear pore complex-interacting protein family member B8 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28928825..28939457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PQR5.1 GenPept UniProtKB/Swiss-Prot:E9PQR5

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