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Ccsap centriole, cilia and spindle associated protein [ Mus musculus (house mouse) ]

Gene ID: 73420, updated on 27-Nov-2024

Summary

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Official Symbol
Ccsapprovided by MGI
Official Full Name
centriole, cilia and spindle associated proteinprovided by MGI
Primary source
MGI:MGI:1920670
See related
Ensembl:ENSMUSG00000031971 AllianceGenome:MGI:1920670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700054N08Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle microtubule depolymerization; regulation of embryonic development; and regulation of mitotic spindle assembly. Predicted to be located in centrosome; cilium; and mitotic spindle astral microtubule. Predicted to be active in axon; ciliary transition zone; and cytoskeleton. Is expressed in olfactory epithelium; telencephalon ventricular layer; and vomeronasal organ. Orthologous to human CCSAP (centriole, cilia and spindle associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 14.9), testis adult (RPKM 12.7) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Ccsap in Genome Data Viewer
Location:
8 E2; 8 72.22 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124566712..124586948, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123839973..123860209, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36188 Neighboring gene RAB4A, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_22987 Neighboring gene STARR-positive B cell enhancer ABC_E5049 Neighboring gene predicted gene 4342 Neighboring gene predicted gene 9901 Neighboring gene predicted gene, 36896 Neighboring gene predicted gene, 53468

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary transition zone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitotic spindle astral microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle astral microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
centriole, cilia and spindle-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379289.1 → NP_001366218.1  centriole, cilia and spindle-associated protein

    Status: VALIDATED

    Source sequence(s)
    AC147266, AK006786, AK086180
    UniProtKB/Swiss-Prot
    Q8C3E1, Q8QZT2
    Related
    ENSMUSP00000034452.6, ENSMUST00000034452.12
    Conserved Domains (1) summary
    pfam15748
    Location:7 → 251
    CCSAP; Centriole, cilia and spindle-associated

  2. NM_028536.1 → NP_082812.1  centriole, cilia and spindle-associated protein

    See identical proteins and their annotated locations for NP_082812.1

    Status: VALIDATED

    Source sequence(s)
    BC036300
    Consensus CDS
    CCDS22763.1
    UniProtKB/Swiss-Prot
    Q8C3E1, Q8QZT2
    Related
    ENSMUSP00000113319.2, ENSMUST00000122421.2
    Conserved Domains (1) summary
    pfam15748
    Location:7 → 251
    CCSAP; Centriole, cilia and spindle-associated

RNA

  1. NR_166592.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC147266

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124566712..124586948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZT2.1 GenPept UniProtKB/Swiss-Prot:Q8QZT2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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