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Dmkn dermokine [ Mus musculus (house mouse) ]

Gene ID: 73712, updated on 27-Nov-2024

Summary

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Official Symbol
Dmknprovided by MGI
Official Full Name
dermokineprovided by MGI
Primary source
MGI:MGI:1920962
See related
Ensembl:ENSMUSG00000060962 AllianceGenome:MGI:1920962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SK30; SK89; cI-36; C130074A08; 1110014F24Rik
Summary
Acts upstream of or within cornified envelope assembly. Located in extracellular space. Is expressed in epidermis; nasal cavity epithelium; nose; posterior naris epithelium; and skin. Orthologous to human DMKN (dermokine). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 182.1), lung adult (RPKM 34.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Dmkn in Genome Data Viewer
Location:
7 B1; 7 19.24 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30463181..30480491)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30763756..30781066)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11349 Neighboring gene transmembrane protein 147 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene suprabasin Neighboring gene STARR-seq mESC enhancer starr_18532 Neighboring gene keratinocyte differentiation associated protein Neighboring gene predicted gene, 32236 Neighboring gene free fatty acid receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homeostatic Function of Dermokine in the Skin Barrier and Inflammation. Utsunomiya A, et al. J Invest Dermatol, 2020 Apr. PMID 31669414
  2. Overexpression of Dermokine-α enhances the proliferation and epithelial-mesenchymal transition of pancreatic tumor cells. Zhang Y, et al. Cell Signal, 2022 Nov. PMID 35981655
  3. Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects. Leclerc EA, et al. J Cell Sci, 2014 Jul 1. PMID 24794495
  4. Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing. Hasegawa M, et al. J Dermatol Sci, 2013 Apr. PMID 23428944
  5. Dermokine: an extensively differentially spliced gene expressed in epithelial cells. Naso MF, et al. J Invest Dermatol, 2007 Jul. PMID 17380110

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of Dermokine-alpha enhances the proliferation and epithelial-mesenchymal transition of pancreatic tumor cells.
    Title: Overexpression of Dermokine-α enhances the proliferation and epithelial-mesenchymal transition of pancreatic tumor cells.
  2. Authors improved the knowledge of Dmkn expression in mouse and highlighted a role for Dmkn beta and gamma in cornification.
    Title: Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects.
  3. These results suggest that dermokine-beta delays early cutaneous wound healing in part by inhibiting expression of CXC chemokines containing the ERL-sequence motif.
    Title: Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.
  4. Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice.
    Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.
  5. Dermokine gene is expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex.
    Title: Dermokine: an extensively differentially spliced gene expressed in epithelial cells.
  6. identification of a novel gene (dermokine)giving rise to two splicing variants, both of which are expressed in the spinous layer of epidermis
    Title: Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cornified envelope assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cornified envelope assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dermokine
Names
epidermis-specific secreted protein SK30/SK89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166173.1 → NP_001159645.1  dermokine isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC165340, AK081753
    Consensus CDS
    CCDS52183.1
    UniProtKB/Swiss-Prot
    Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0
    UniProtKB/TrEMBL
    E9Q2P1
    Related
    ENSMUSP00000129031.2, ENSMUST00000165887.8
    Conserved Domains (1) summary
    PRK13875
    Location:22 → 155
    PRK13875; conjugal transfer protein TrbL; Provisional

  2. NM_001166174.1 → NP_001159646.1  dermokine isoform d precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AC165340, AK081753, BC064724
    Consensus CDS
    CCDS52184.1
    UniProtKB/Swiss-Prot
    Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0
    UniProtKB/TrEMBL
    E9QLW8
    Related
    ENSMUSP00000082831.5, ENSMUST00000085688.11
    Conserved Domains (1) summary
    PRK13875
    Location:22 → 155
    PRK13875; conjugal transfer protein TrbL; Provisional

  3. NM_001369359.1 → NP_001356288.1  dermokine isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC165340
    UniProtKB/Swiss-Prot
    Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0
    Conserved Domains (1) summary
    PRK13875
    Location:22 → 155
    PRK13875; conjugal transfer protein TrbL; Provisional

  4. NM_028618.2 → NP_082894.1  dermokine isoform a precursor

    See identical proteins and their annotated locations for NP_082894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1, also called alpha) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AC165340, AK003695
    Consensus CDS
    CCDS39893.1
    UniProtKB/Swiss-Prot
    Q6P253
    Related
    ENSMUSP00000042300.8, ENSMUST00000041703.10

  5. NM_172899.4 → NP_766487.3  dermokine isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2, also called beta) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AC165340, AK081753, BC064724
    Consensus CDS
    CCDS39892.1
    UniProtKB/Swiss-Prot
    Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0
    UniProtKB/TrEMBL
    E9QLW7
    Related
    ENSMUSP00000082834.5, ENSMUST00000085691.11
    Conserved Domains (1) summary
    PRK13875
    Location:22 → 155
    PRK13875; conjugal transfer protein TrbL; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30463181..30480491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P253.2 GenPept UniProtKB/Swiss-Prot:Q6P253

Gene LinkOut

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