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Mcee methylmalonyl CoA epimerase [ Mus musculus (house mouse) ]

Gene ID: 73724, updated on 27-Nov-2024

Summary

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Official Symbol
Mceeprovided by MGI
Official Full Name
methylmalonyl CoA epimeraseprovided by MGI
Primary source
MGI:MGI:1920974
See related
Ensembl:ENSMUSG00000033429 AllianceGenome:MGI:1920974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110007A04Rik
Summary
Predicted to enable methylmalonyl-CoA epimerase activity. Predicted to be involved in L-methylmalonyl-CoA metabolic process. Located in mitochondrion. Is expressed in central nervous system; choroid plexus; and nervous system. Orthologous to human MCEE (methylmalonyl-CoA epimerase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 21.9), kidney adult (RPKM 21.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mcee in Genome Data Viewer
Location:
7 34.65 cM; 7 C
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (64042370..64061869)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (64392622..64412121)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19038 Neighboring gene STARR-seq mESC enhancer starr_19039 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71537088-71537271 Neighboring gene STARR-positive B cell enhancer ABC_E4931 Neighboring gene M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) Neighboring gene SET translocation pseudogene Neighboring gene FANCD2/FANCI-associated nuclease 1 Neighboring gene STARR-seq mESC enhancer starr_19041 Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene STARR-seq mESC enhancer starr_19042 Neighboring gene STARR-seq mESC enhancer starr_19043 Neighboring gene endosomal transmembrane epsin interactor 2 Neighboring gene STARR-seq mESC enhancer starr_19044 Neighboring gene STARR-seq mESC enhancer starr_19045 Neighboring gene NSE3 homolog, SMC5-SMC6 complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. Stefan M, et al. BMC Genomics, 2005 Nov 9. PMID 16280085, Free PMC Article
  2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylmalonyl-CoA epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylmalonyl-CoA epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables methylmalonyl-CoA epimerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-methylmalonyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-methylmalonyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methylmalonyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
methylmalonyl-CoA epimerase, mitochondrial
Names
DL-methylmalonyl-CoA racemase
NP_001342053.1
NP_082902.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355124.1 → NP_001342053.1  methylmalonyl-CoA epimerase, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC129199
    Consensus CDS
    CCDS90248.1
    UniProtKB/TrEMBL
    A0A0U1RQ27
    Related
    ENSMUSP00000146220.2, ENSMUST00000206194.2
    Conserved Domains (1) summary
    cl14632
    Location:49 → 123
    VOC; vicinal oxygen chelate (VOC) family

  2. NM_028626.2 → NP_082902.1  methylmalonyl-CoA epimerase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_082902.1

    Status: VALIDATED

    Source sequence(s)
    AC129199
    Consensus CDS
    CCDS21334.1
    UniProtKB/Swiss-Prot
    Q9D1I5
    Related
    ENSMUSP00000047855.9, ENSMUST00000037205.11
    Conserved Domains (1) summary
    TIGR03081
    Location:49 → 177
    metmalonyl_epim; methylmalonyl-CoA epimerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    64042370..64061869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1I5.1 GenPept UniProtKB/Swiss-Prot:Q9D1I5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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