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Slc35b2 solute carrier family 35, member B2 [ Mus musculus (house mouse) ]

Gene ID: 73836, updated on 27-Nov-2024

Summary

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Official Symbol
Slc35b2provided by MGI
Official Full Name
solute carrier family 35, member B2provided by MGI
Primary source
MGI:MGI:1921086
See related
Ensembl:ENSMUSG00000037089 AllianceGenome:MGI:1921086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAPST1; Slc35b1; 1110003M08Rik
Summary
Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 5'-adenylyl sulfate transmembrane transport and peptidyl-tyrosine sulfation. Is active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including cerebral cortex ventricular layer; craniocervical region bone; otic capsule; retina nuclear layer; and shoulder bone. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Orthologous to human SLC35B2 (solute carrier family 35 member B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 50.2), colon adult (RPKM 39.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc35b2 in Genome Data Viewer
Location:
17 B3; 17 22.59 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45874844..45878597)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45563913..45567671)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene t-complex-associated testis expressed 1 Neighboring gene transmembrane protein 151B Neighboring gene STARR-positive B cell enhancer ABC_E7533 Neighboring gene STARR-positive B cell enhancer ABC_E961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45695258-45695367 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon Neighboring gene STARR-positive B cell enhancer ABC_E10954 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45710735-45710975 Neighboring gene predicted gene, 35399

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells. Sasaki N, et al. PLoS One, 2009 Dec 11. PMID 20011239, Free PMC Article
  2. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1, PAPST2]
    Title: The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in 5'-adenylyl sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in chondroitin sulfate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-tyrosine sulfation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenosine 3'-phospho 5'-phosphosulfate transporter 1
Names
PAPS transporter 1
solute carrier family 35, member B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357105.1 → NP_001344034.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1

    Status: VALIDATED

    Source sequence(s)
    AI842275, AK144403, AK152362, BB855705, BB871150
    Consensus CDS
    CCDS37630.2
    UniProtKB/Swiss-Prot
    Q3U221, Q8BTH2, Q91ZN5
    UniProtKB/TrEMBL
    Q3U399, Q3U866
    Related
    ENSMUSP00000153367.2, ENSMUST00000224905.2
    Conserved Domains (1) summary
    pfam08449
    Location:111 → 412
    UAA; UAA transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45874844..45878597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160806.1 → XP_036016699.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform X1

    UniProtKB/TrEMBL
    Q3TJQ2
    Conserved Domains (1) summary
    pfam08449
    Location:31 → 326
    UAA; UAA transporter family

  2. XM_036160807.1 → XP_036016700.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform X2

    UniProtKB/TrEMBL
    Q3TJQ2
    Related
    ENSMUSP00000153631.2, ENSMUST00000223987.2
    Conserved Domains (1) summary
    pfam08449
    Location:106 → 407
    UAA; UAA transporter family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028662.2: Suppressed sequence

    Description
    NM_028662.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZN5.1 GenPept UniProtKB/Swiss-Prot:Q91ZN5

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