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Jakmip3 janus kinase and microtubule interacting protein 3 [ Mus musculus (house mouse) ]

Gene ID: 74004, updated on 4-Jan-2025

Summary

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Official Symbol
Jakmip3provided by MGI
Official Full Name
janus kinase and microtubule interacting protein 3provided by MGI
Primary source
MGI:MGI:1921254
See related
Ensembl:ENSMUSG00000056856 AllianceGenome:MGI:1921254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4091; 6330417G02Rik
Summary
Predicted to enable kinase binding activity and microtubule binding activity. Predicted to be located in Golgi apparatus. Orthologous to human JAKMIP3 (Janus kinase and microtubule interacting protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cerebellum adult (RPKM 6.7), cortex adult (RPKM 6.6) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Jakmip3 in Genome Data Viewer
Location:
7 F4; 7 83.0 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138542057..138663893)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (138940730..139083976)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20412 Neighboring gene STARR-positive B cell enhancer ABC_E11372 Neighboring gene gamma-glutamyl hydrolase pseudogene Neighboring gene BCL2/adenovirus E1B interacting protein 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_20414 Neighboring gene dihydropyrimidinase-like 4 Neighboring gene serine/threonine kinase 32C Neighboring gene STARR-positive B cell enhancer ABC_E11373 Neighboring gene STARR-positive B cell enhancer ABC_E296 Neighboring gene leucine rich repeat containing 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E (-/-) mice. Mu X, et al. Free Radic Biol Med, 2024 Apr. PMID 38461872
  2. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E [-/-] mice.
    Title: The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E (-/-) mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4091

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
janus kinase and microtubule-interacting protein 3
Names
neuroendocrine long coiled-coil protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433479.1 → NP_001420408.1  janus kinase and microtubule-interacting protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC174642, AC241620, AEKQ02141041, AEKQ02141042

  2. NM_028708.2 → NP_082984.1  janus kinase and microtubule-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_082984.1

    Status: VALIDATED

    Source sequence(s)
    AK018189, AK220482
    UniProtKB/Swiss-Prot
    Q0VDR4, Q0VDR5, Q5DTN8, Q9CU41
    Related
    ENSMUSP00000130207.4, ENSMUST00000166163.4
    Conserved Domains (2) summary
    TIGR02168
    Location:8 → 816
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16034
    Location:430 → 626
    JAKMIP_CC3; JAKMIP CC3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    138542057..138663893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153483.1 → XP_036009376.1  janus kinase and microtubule-interacting protein 3 isoform X2

    Conserved Domains (2) summary
    PHA02682
    Location:411 → 530
    PHA02682; ORF080 virion core protein; Provisional
    COG1196
    Location:8 → 360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_036153486.1 → XP_036009379.1  janus kinase and microtubule-interacting protein 3 isoform X4

    Conserved Domains (2) summary
    PHA02682
    Location:339 → 458
    PHA02682; ORF080 virion core protein; Provisional
    COG1196
    Location:13 → 315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_036153488.1 → XP_036009381.1  janus kinase and microtubule-interacting protein 3 isoform X5

    Conserved Domains (2) summary
    PHA02682
    Location:337 → 456
    PHA02682; ORF080 virion core protein; Provisional
    COG1196
    Location:13 → 301
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_036153490.1 → XP_036009383.1  janus kinase and microtubule-interacting protein 3 isoform X7

    Conserved Domains (2) summary
    PHA02682
    Location:336 → 455
    PHA02682; ORF080 virion core protein; Provisional
    COG1196
    Location:13 → 300
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_036153485.1 → XP_036009378.1  janus kinase and microtubule-interacting protein 3 isoform X4

    Conserved Domains (2) summary
    PHA02682
    Location:339 → 458
    PHA02682; ORF080 virion core protein; Provisional
    COG1196
    Location:13 → 315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_036153487.1 → XP_036009380.1  janus kinase and microtubule-interacting protein 3 isoform X5

    Conserved Domains (2) summary
    PHA02682
    Location:337 → 456
    PHA02682; ORF080 virion core protein; Provisional
    COG1196
    Location:13 → 301
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_036153484.1 → XP_036009377.1  janus kinase and microtubule-interacting protein 3 isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:8 → 366
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16034
    Location:430 → 533
    JAKMIP_CC3; JAKMIP CC3 domain

  8. XM_036153481.1 → XP_036009374.1  janus kinase and microtubule-interacting protein 3 isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:8 → 825
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16034
    Location:430 → 627
    JAKMIP_CC3; JAKMIP CC3 domain

  9. XM_036153482.1 → XP_036009375.1  janus kinase and microtubule-interacting protein 3 isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:8 → 825
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16034
    Location:430 → 627
    JAKMIP_CC3; JAKMIP CC3 domain

  10. XM_036153489.1 → XP_036009382.1  janus kinase and microtubule-interacting protein 3 isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:26 → 303
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16034
    Location:358 → 462
    JAKMIP_CC3; JAKMIP CC3 domain

  11. XM_036153491.1 → XP_036009384.1  janus kinase and microtubule-interacting protein 3 isoform X8

    Conserved Domains (2) summary
    COG1196
    Location:26 → 301
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16034
    Location:356 → 460
    JAKMIP_CC3; JAKMIP CC3 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTN8.2 GenPept UniProtKB/Swiss-Prot:Q5DTN8

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