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Cep55 centrosomal protein 55 [ Mus musculus (house mouse) ]

Gene ID: 74107, updated on 27-Nov-2024

Summary

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Official Symbol
Cep55provided by MGI
Official Full Name
centrosomal protein 55provided by MGI
Primary source
MGI:MGI:1921357
See related
Ensembl:ENSMUSG00000024989 AllianceGenome:MGI:1921357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200008O12Rik; 2700032M20Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Located in intercellular bridge and midbody. Is expressed in cerebral cortex ventricular layer; germ cell of testis; and ovary. Used to study Meckel syndrome. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Orthologous to human CEP55 (centrosomal protein 55). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 14.2), placenta adult (RPKM 6.0) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Cep55 in Genome Data Viewer
Location:
19 C2; 19 32.69 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38043423..38062873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38054970..38074425)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene myoferlin Neighboring gene predicted gene, 52397 Neighboring gene STARR-positive B cell enhancer mm9_chr19:38100719-38101020 Neighboring gene predicted gene, 52396 Neighboring gene STARR-seq mESC enhancer starr_46072 Neighboring gene STARR-positive B cell enhancer ABC_E971 Neighboring gene STARR-seq mESC enhancer starr_46073 Neighboring gene STARR-seq mESC enhancer starr_46074 Neighboring gene predicted gene, 23300 Neighboring gene free fatty acid receptor 4 Neighboring gene retinol binding protein 4, plasma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knowing when to cut and run: mechanisms that control cytokinetic abscission. Agromayor M, et al. Trends Cell Biol, 2013 Sep. PMID 23706391
  2. Cep55 regulates spindle organization and cell cycle progression in meiotic oocyte. Xu ZY, et al. Sci Rep, 2015 Nov 19. PMID 26582107, Free PMC Article
  3. Cep55 overexpression promotes genomic instability and tumorigenesis in mice. Sinha D, et al. Commun Biol, 2020 Oct 21. PMID 33087841, Free PMC Article
  4. Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis. Jeffery J, et al. Oncogene, 2016 Feb 11. PMID 25915844
  5. CEP proteins: the knights of centrosome dynasty. Kumar A, et al. Protoplasma, 2013 Oct. PMID 23456457

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55.
    Title: Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55.
  2. alpha-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.
    Title: α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.
  3. MicroRNA-449a Suppresses Mouse Spermatogonia Proliferation via Inhibition of CEP55.
    Title: MicroRNA-449a Suppresses Mouse Spermatogonia Proliferation via Inhibition of CEP55.
  4. CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
    Title: CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
  5. Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
    Title: Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
  6. Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
    Title: Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
  7. This work defines Cep55 as an abscission regulator.
    Title: Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
  8. Study found that Cep55-depleted mouse oocytes progress normally through early meiosis I, but that anaphase I fails as a result of persistent Cdk1 activity.
    Title: First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation.
  9. that Cep55 overexpression causes change in germ cell proportions and manifests as a Sertoli cell only tubule phenotype
    Title: Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.
  10. Cep55 may act as an MTOC-associated protein regulating spindle organization, and thus cell cycle progression during mouse oocyte meiotic maturation.
    Title: Cep55 regulates spindle organization and cell cycle progression in meiotic oocyte.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cranial skeletal system development ISO
Inferred from Sequence Orthology
more info
  
involved_in cranial skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in midbody abscission IEA
Inferred from Electronic Annotation
more info
  
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
located_in Flemming body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 55 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164362.2 → NP_001157834.1  centrosomal protein of 55 kDa isoform 1

    See identical proteins and their annotated locations for NP_001157834.1

    Status: VALIDATED

    Source sequence(s)
    AC101774, AK004655, AW538141
    Consensus CDS
    CCDS50429.1
    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Related
    ENSMUSP00000127961.2, ENSMUST00000169673.3
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  2. NM_001360663.1 → NP_001347592.1  centrosomal protein of 55 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101774
    Consensus CDS
    CCDS50429.1
    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Related
    ENSMUSP00000157898.2, ENSMUST00000236044.2
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  3. NM_028293.2 → NP_082569.1  centrosomal protein of 55 kDa isoform 1

    See identical proteins and their annotated locations for NP_082569.1

    Status: VALIDATED

    Source sequence(s)
    AC101774, AK004655, AK028216, AW538141, CJ074252
    Consensus CDS
    CCDS50429.1
    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Related
    ENSMUSP00000093802.5, ENSMUST00000096096.12
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  4. NM_028760.3 → NP_083036.2  centrosomal protein of 55 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101774, AK004655, AW538141
    Consensus CDS
    CCDS29782.1
    UniProtKB/Swiss-Prot
    Q8BT07
    Related
    ENSMUSP00000157871.2, ENSMUST00000237408.2
    Conserved Domains (2) summary
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55
    cl19219
    Location:256 → 332
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    38043423..38062873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527396.3 → XP_006527459.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527459.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  2. XM_006527399.4 → XP_006527462.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527462.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  3. XM_006527401.2 → XP_006527464.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527464.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  4. XM_030251115.2 → XP_030106975.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78 → 244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:17 → 50
    EABR; TSG101 and ALIX binding domain of CEP55

  5. XM_006527402.3 → XP_006527465.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78 → 244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:17 → 50
    EABR; TSG101 and ALIX binding domain of CEP55

  6. XM_030251114.2 → XP_030106974.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78 → 244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:17 → 50
    EABR; TSG101 and ALIX binding domain of CEP55

  7. XM_006527397.5 → XP_006527460.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527460.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  8. XM_011247381.4 → XP_011245683.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_011245683.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  9. XM_006527398.5 → XP_006527461.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527461.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  10. XM_036161710.1 → XP_036017603.1  centrosomal protein of 55 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171 → 204
    EABR; TSG101 and ALIX binding domain of CEP55

  11. XM_036161711.1 → XP_036017604.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78 → 244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:17 → 50
    EABR; TSG101 and ALIX binding domain of CEP55

  12. XM_030251113.2 → XP_030106973.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78 → 244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:17 → 50
    EABR; TSG101 and ALIX binding domain of CEP55

  13. XM_036161712.1 → XP_036017605.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78 → 244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:17 → 50
    EABR; TSG101 and ALIX binding domain of CEP55
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BT07.2 GenPept UniProtKB/Swiss-Prot:Q8BT07

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