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Cluh clustered mitochondria homolog [ Mus musculus (house mouse) ]

Gene ID: 74148, updated on 27-Nov-2024

Summary

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Official Symbol
Cluhprovided by MGI
Official Full Name
clustered mitochondria homologprovided by MGI
Primary source
MGI:MGI:1921398
See related
Ensembl:ENSMUSG00000020741 AllianceGenome:MGI:1921398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0664; mKIAA0664; 1300001I01Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in intracellular distribution of mitochondria. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; musculature; and naris. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 48.6), adrenal adult (RPKM 47.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cluh in Genome Data Viewer
Location:
11 B5; 11 45.76 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74539707..74561680)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74648881..74670854)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E7014 Neighboring gene STARR-seq mESC enhancer starr_29957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:74369680-74369789 Neighboring gene STARR-seq mESC enhancer starr_29960 Neighboring gene STARR-seq mESC enhancer starr_29961 Neighboring gene STARR-seq mESC enhancer starr_29962 Neighboring gene predicted gene, 50590 Neighboring gene coiled-coil domain containing 92B Neighboring gene STARR-positive B cell enhancer ABC_E3971 Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 Neighboring gene STARR-seq mESC enhancer starr_29966 Neighboring gene predicted gene, 24211

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice. Ralevski A, et al. Cell Mol Life Sci, 2022 Jun 2. PMID 35652974, Free PMC Article
  2. Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA. Singh S, et al. Basic Res Cardiol, 2023 Nov 3. PMID 37923788
  3. CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy. Pla-Martín D, et al. EMBO J, 2020 May 4. PMID 32149416, Free PMC Article
  4. CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy. Zaninello M, et al. Sci Adv, 2024 May 31. PMID 38809982, Free PMC Article
  5. CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. Schatton D, et al. J Cell Biol, 2017 Mar 6. PMID 28188211, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy.
    Title: CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy.
  2. Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
    Title: Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
  3. Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
    Title: Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
  4. CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.
    Title: CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intracellular distribution of mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular distribution of mitochondria ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular distribution of mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
clustered mitochondria protein homolog
Names
clustered mitochondria (cluA/CLU1) homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081158.3 → NP_001074627.1  clustered mitochondria protein homolog isoform 1

    See identical proteins and their annotated locations for NP_001074627.1

    Status: VALIDATED

    Source sequence(s)
    AL607024, AL645971
    Consensus CDS
    CCDS36223.1
    UniProtKB/TrEMBL
    A0A0R4J140, Z4YLI8
    Related
    ENSMUSP00000090593.6, ENSMUST00000092915.12
    Conserved Domains (6) summary
    sd00006
    Location:1062 → 1088
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:809 → 988
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:394 → 614
    CLU; Clustered mitochondria
    pfam13374
    Location:1061 → 1100
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:1140 → 1217
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:104 → 177
    CLU_N; Mitochondrial function, CLU-N-term

  2. NM_001368711.1 → NP_001355640.1  clustered mitochondria protein homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL607024, AL645971
    UniProtKB/Swiss-Prot
    A8Y5E2, Q3U014, Q3U4M5, Q3V3Q8, Q505Q6, Q5SW19, Q6GQX1, Q6PAT1, Q8CHD9
    UniProtKB/TrEMBL
    Z4YLI8
    Conserved Domains (5) summary
    sd00006
    Location:1024 → 1050
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1104 → 1179
    TPR_12; Tetratricopeptide repeat
    pfam12807
    Location:769 → 950
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356 → 576
    CLU; Clustered mitochondria
    pfam15044
    Location:66 → 139
    CLU_N; Mitochondrial function, CLU-N-term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    74539707..74561680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314805.3 → XP_017170294.1  clustered mitochondria protein homolog isoform X1

    UniProtKB/TrEMBL
    Z4YLI8
    Conserved Domains (5) summary
    sd00006
    Location:1061 → 1087
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1141 → 1216
    TPR_12; Tetratricopeptide repeat
    pfam12807
    Location:806 → 987
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:394 → 614
    CLU; Clustered mitochondria
    pfam15044
    Location:104 → 177
    CLU_N; Mitochondrial function, CLU-N-term

  2. XM_006534353.4 → XP_006534416.1  clustered mitochondria protein homolog isoform X2

    See identical proteins and their annotated locations for XP_006534416.1

    UniProtKB/Swiss-Prot
    A8Y5E2, Q3U014, Q3U4M5, Q3V3Q8, Q505Q6, Q5SW19, Q6GQX1, Q6PAT1, Q8CHD9
    UniProtKB/TrEMBL
    Z4YLI8
    Conserved Domains (5) summary
    sd00006
    Location:1024 → 1050
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1104 → 1179
    TPR_12; Tetratricopeptide repeat
    pfam12807
    Location:769 → 950
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356 → 576
    CLU; Clustered mitochondria
    pfam15044
    Location:66 → 139
    CLU_N; Mitochondrial function, CLU-N-term
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SW19.2 GenPept UniProtKB/Swiss-Prot:Q5SW19

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