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Gale galactose-4-epimerase, UDP [ Mus musculus (house mouse) ]

Gene ID: 74246, updated on 4-Jan-2025

Summary

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Official Symbol
Galeprovided by MGI
Official Full Name
galactose-4-epimerase, UDPprovided by MGI
Primary source
MGI:MGI:1921496
See related
Ensembl:ENSMUSG00000028671 AllianceGenome:MGI:1921496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310002A12Rik
Summary
Enables UDP-glucose 4-epimerase activity. Involved in galactose catabolic process via UDP-galactose. Acts upstream of or within galactose metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in galactose epimerase deficiency and thrombocytopenia. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in colon adult (RPKM 100.7), large intestine adult (RPKM 78.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Gale in Genome Data Viewer
Location:
4 D3; 4 68.29 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135690550..135695489)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135963681..135968178)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4685 Neighboring gene fucosidase, alpha-L- 1, tissue Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase Neighboring gene STARR-positive B cell enhancer ABC_E4686 Neighboring gene STARR-positive B cell enhancer ABC_E3529 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135528566-135528675 Neighboring gene lysophospholipase 2 Neighboring gene PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression. Zhu Y, et al. Diabetes, 2017 Nov. PMID 28877911, Free PMC Article
  2. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. Deng Y, et al. J Clin Invest, 2013 Jan. PMID 23257357, Free PMC Article
  3. Galactitol and galactonate accumulation in heart and skeletal muscle of mice with deficiency of galactose-1-phosphate uridyltransferase. Yager C, et al. Mol Genet Metab, 2004 Feb. PMID 14741191
  4. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose 4-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose 4-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose 4-epimerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables UDP-glucose 4-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in galactose catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within galactose catabolic process via UDP-galactose IC
Inferred by Curator
more info
 PubMed 
involved_in galactose catabolic process via UDP-galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within galactose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycolytic process from galactose IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDP-glucose 4-epimerase
Names
UDP-GalNAc 4-epimerase
UDP-GlcNAc 4-epimerase
UDP-N-acetylglucosamine 4-epimerase
UDP-galactosamine 4-epimerase
UDP-galactose 4-epimerase
galactowaldenase
NP_001343422.1
XP_006539281.1
XP_006539282.1
XP_030109702.1
XP_030109703.1
XP_030109704.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356493.1 → NP_001343422.1  UDP-glucose 4-epimerase

    Status: VALIDATED

    Source sequence(s)
    AI847878, AL672076, AW544394, BB854114, BG077710, CO429161
    Consensus CDS
    CCDS18796.1
    UniProtKB/Swiss-Prot
    Q8R059
    Related
    ENSMUSP00000099600.4, ENSMUST00000102541.10
    Conserved Domains (1) summary
    cd05247
    Location:3 → 337
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135690550..135695489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253842.2 → XP_030109702.1  UDP-glucose 4-epimerase isoform X2

    Conserved Domains (1) summary
    cd05247
    Location:1 → 220
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  2. XM_006539219.5 → XP_006539282.1  UDP-glucose 4-epimerase isoform X1

    See identical proteins and their annotated locations for XP_006539282.1

    UniProtKB/Swiss-Prot
    Q8R059
    Conserved Domains (1) summary
    cd05247
    Location:3 → 337
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  3. XM_006539218.5 → XP_006539281.1  UDP-glucose 4-epimerase isoform X1

    See identical proteins and their annotated locations for XP_006539281.1

    UniProtKB/Swiss-Prot
    Q8R059
    Conserved Domains (1) summary
    cd05247
    Location:3 → 337
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  4. XM_030253843.2 → XP_030109703.1  UDP-glucose 4-epimerase isoform X2

    Conserved Domains (1) summary
    cd05247
    Location:1 → 220
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  5. XM_030253844.2 → XP_030109704.1  UDP-glucose 4-epimerase isoform X2

    Conserved Domains (1) summary
    cd05247
    Location:1 → 220
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

RNA

  1. XR_003955031.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178389.3: Suppressed sequence

    Description
    NM_178389.3: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R059.1 GenPept UniProtKB/Swiss-Prot:Q8R059

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