Smu1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smu1provided by MGI
Official Full Name: smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)provided by MGI
Primary source: MGI:MGI:1915546
See related: Ensembl:ENSMUSG00000028409 AllianceGenome:MGI:1915546
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bwd; 2600001O03Rik; 2610203K23Rik
Summary: Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; genitourinary system; liver; otocyst; and retina. Orthologous to human SMU1 (SMU1 DNA replication regulator and spliceosomal factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 30.9), placenta adult (RPKM 27.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 20.46 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (40735649..40757885, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (40735649..40757885, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130392 (e-PCR)
- UniSTS:213676

AW556129 (e-PCR)
- UniSTS:185577

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type precatalytic spliceosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of precatalytic spliceosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD40 repeat-containing protein SMU1

Names: smu-1 suppressor of mec-8 and unc-52 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021535.4 → NP_067510.3 WD40 repeat-containing protein SMU1

See identical proteins and their annotated locations for NP_067510.3

Status: VALIDATED

Source sequence(s)

AK145982, AK163758, AK168813, BY036103

Consensus CDS

CCDS18050.1

UniProtKB/Swiss-Prot

Q3UKJ7, Q6PFR6, Q8BMY4, Q9D1I8, Q9JJ70

Related

ENSMUSP00000030117.5, ENSMUST00000030117.5

Conserved Domains (5) summary

smart00668
Location:40 → 90

CTLH; C-terminal to LisH motif

COG4598
Location:102 → 218

HisP; ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]

cd00200
Location:205 → 512

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:219 → 262

7WD40; WD40 repeat [structural motif]

pfam17814
Location:7 → 36

LisH_TPL; LisH-like dimerisation domain