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Ubap2l ubiquitin-associated protein 2-like [ Mus musculus (house mouse) ]

Gene ID: 74383, updated on 27-Nov-2024

Summary

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Official Symbol
Ubap2lprovided by MGI
Official Full Name
ubiquitin-associated protein 2-likeprovided by MGI
Primary source
MGI:MGI:1921633
See related
Ensembl:ENSMUSG00000042520 AllianceGenome:MGI:1921633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nice-4; mKIAA0144; 3110083O19Rik; 4932431F02Rik; A430103N23Rik
Summary
Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in chromosome and cytoplasmic stress granule. Predicted to be part of PcG protein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in lung epithelium. Orthologous to human UBAP2L (ubiquitin associated protein 2 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 19.2), testis adult (RPKM 17.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ubap2l in Genome Data Viewer
Location:
3 F1; 3 39.19 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89906896..89959867, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89999589..90052609, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene aquaporin 10, pseudogene Neighboring gene predicted gene, 24046 Neighboring gene STARR-positive B cell enhancer ABC_E4557 Neighboring gene predicted gene, 19710 Neighboring gene HCLS1 associated X-1 Neighboring gene predicted gene, 24608 Neighboring gene microRNA 7669 Neighboring gene RIKEN cDNA 4933434E20 gene Neighboring gene STARR-seq mESC enhancer starr_08270 Neighboring gene cilia and flagella associated protein 141 Neighboring gene microRNA 190b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of ubiquitin associated protein 2-like inhibits the growth and migration of prostate cancer cells. Li D, et al. Oncol Rep, 2014 Oct. PMID 25069639
  2. UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis. Aucagne R, et al. FASEB J, 2017 Nov. PMID 28754713
  3. Three-dimensional microCT imaging of mouse heart development from early post-implantation to late fetal stages. Li-Villarreal N, et al. Mamm Genome, 2023 Jun. PMID 36595063, Free PMC Article
  4. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Bordeleau ME, et al. Blood, 2014 Oct 9. PMID 25185265, Free PMC Article
  5. lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins. Kuniyoshi H, et al. Genetics, 2002 Dec. PMID 12524348, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation
  • Transgenic (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25504

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
  
involved_in binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic stem cell homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-associated protein 2-like
Names
Nice-4 protein homolog
RNA polymerase II degradation factor Ubap2l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165983.2 → NP_001159455.1  ubiquitin-associated protein 2-like isoform 3

    See identical proteins and their annotated locations for NP_001159455.1

    Status: VALIDATED

    Source sequence(s)
    AC163616, AK048286, BM124250, CK344187
    Consensus CDS
    CCDS50966.1
    UniProtKB/TrEMBL
    Q812D5
    Related
    ENSMUSP00000066138.9, ENSMUST00000064639.15
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:521 → 548
    DUF3697; Ubiquitin-associated protein 2

  2. NM_001165984.1 → NP_001159456.1  ubiquitin-associated protein 2-like isoform 4

    See identical proteins and their annotated locations for NP_001159456.1

    Status: VALIDATED

    Source sequence(s)
    AK048286, BB842333, BC050910
    Consensus CDS
    CCDS79960.1
    UniProtKB/Swiss-Prot
    Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6
    UniProtKB/TrEMBL
    Q812D5
    Related
    ENSMUSP00000143459.2, ENSMUST00000196843.5
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:516 → 543
    DUF3697; Ubiquitin-associated protein 2

  3. NM_001165985.2 → NP_001159457.1  ubiquitin-associated protein 2-like isoform 5

    See identical proteins and their annotated locations for NP_001159457.1

    Status: VALIDATED

    Source sequence(s)
    AC163616, AK031934
    Consensus CDS
    CCDS50965.1
    UniProtKB/TrEMBL
    Q8BJ53
    Related
    ENSMUSP00000143638.2, ENSMUST00000195995.5
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:527 → 554
    DUF3697; Ubiquitin-associated protein 2

  4. NM_001165986.1 → NP_001159458.1  ubiquitin-associated protein 2-like isoform 5

    See identical proteins and their annotated locations for NP_001159458.1

    Status: VALIDATED

    Source sequence(s)
    AC163616, AK031934, AK079895, BB842333
    Consensus CDS
    CCDS50965.1
    UniProtKB/TrEMBL
    Q8BJ53
    Related
    ENSMUSP00000143254.2, ENSMUST00000199834.5
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:527 → 554
    DUF3697; Ubiquitin-associated protein 2

  5. NM_001165987.2 → NP_001159459.1  ubiquitin-associated protein 2-like isoform 6

    See identical proteins and their annotated locations for NP_001159459.1

    Status: VALIDATED

    Source sequence(s)
    AC163616, AK031934, BB648932
    Consensus CDS
    CCDS79959.1
    UniProtKB/TrEMBL
    A0A0H2UH17, Q8BJ53
    Related
    ENSMUSP00000088424.8, ENSMUST00000090908.11
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496 → 523
    DUF3697; Ubiquitin-associated protein 2

  6. NM_001165988.1 → NP_001159460.1  ubiquitin-associated protein 2-like isoform 6

    See identical proteins and their annotated locations for NP_001159460.1

    Status: VALIDATED

    Source sequence(s)
    AC163616, AK031934, BB842333
    Consensus CDS
    CCDS79959.1
    UniProtKB/TrEMBL
    A0A0H2UH17, Q8BJ53
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496 → 523
    DUF3697; Ubiquitin-associated protein 2

  7. NM_001357307.1 → NP_001344236.1  ubiquitin-associated protein 2-like isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC163616
    UniProtKB/TrEMBL
    Q812D5
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507 → 534
    DUF3697; Ubiquitin-associated protein 2

  8. NM_028475.3 → NP_082751.1  ubiquitin-associated protein 2-like isoform 1

    See identical proteins and their annotated locations for NP_082751.1

    Status: VALIDATED

    Source sequence(s)
    AC163616, AK016538, BB648932, BC029075, BM935680
    Consensus CDS
    CCDS38498.1
    UniProtKB/TrEMBL
    Q812D5
    Related
    ENSMUSP00000029553.10, ENSMUST00000029553.16
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:516 → 543
    DUF3697; Ubiquitin-associated protein 2

  9. NM_153489.3 → NP_705693.2  ubiquitin-associated protein 2-like isoform 2

    See identical proteins and their annotated locations for NP_705693.2

    Status: VALIDATED

    Source sequence(s)
    AC163616, BB648932
    Consensus CDS
    CCDS79958.1
    UniProtKB/TrEMBL
    A0A0G2JDV6, Q812D5
    Related
    ENSMUSP00000142524.2, ENSMUST00000198322.5
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496 → 523
    DUF3697; Ubiquitin-associated protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89906896..89959867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163363.1 → XP_036019256.1  ubiquitin-associated protein 2-like isoform X1

    UniProtKB/TrEMBL
    Q8BJ53
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:532 → 559
    DUF3697; Ubiquitin-associated protein 2

  2. XM_006502186.2 → XP_006502249.1  ubiquitin-associated protein 2-like isoform X1

    UniProtKB/TrEMBL
    Q8BJ53
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:532 → 559
    DUF3697; Ubiquitin-associated protein 2

  3. XM_011240246.3 → XP_011238548.1  ubiquitin-associated protein 2-like isoform X2

    UniProtKB/TrEMBL
    Q8BJ53
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:532 → 559
    DUF3697; Ubiquitin-associated protein 2

  4. XM_030252854.2 → XP_030108714.1  ubiquitin-associated protein 2-like isoform X3

    UniProtKB/TrEMBL
    Q8BJ53
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496 → 523
    DUF3697; Ubiquitin-associated protein 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X50.1 GenPept UniProtKB/Swiss-Prot:Q80X50

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