U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sap25 sin3 associated polypeptide [ Mus musculus (house mouse) ]

Gene ID: 751865, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Sap25provided by MGI
Official Full Name
sin3 associated polypeptideprovided by MGI
Primary source
MGI:MGI:3802945
See related
Ensembl:ENSMUSG00000079165 AllianceGenome:MGI:3802945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in negative regulation of DNA-templated transcription. Is active in nucleus. Orthologous to human SAP25 (Sin3A associated protein 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 123.8), spleen adult (RPKM 98.3) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sap25 in Genome Data Viewer
Location:
5 G2; 5 76.59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137639735..137641164)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137641473..137642902)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene F-box protein 24 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E72 Neighboring gene STARR-seq mESC enhancer starr_14649 Neighboring gene predicted gene 20605 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 4 Neighboring gene insulin receptor substrate 3 Neighboring gene ArfGAP with FG repeats 2 Neighboring gene STARR-positive B cell enhancer ABC_E236

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. Shiio Y, et al. Mol Cell Biol, 2006 Feb. PMID 16449650, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Readthrough Gm20605

Readthrough gene: Gm20605, Included gene: Lrch4

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
histone deacetylase complex subunit SAP25
Names
25 kDa Sin3-associated polypeptide
mSin3A-binding protein
sin3 corepressor complex subunit SAP25
sin3A-binding protein, SAP25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081962.2 → NP_001075431.2  histone deacetylase complex subunit SAP25

    Status: VALIDATED

    Source sequence(s)
    AM275337, BX517344, CB058897
    Consensus CDS
    CCDS39336.2
    UniProtKB/TrEMBL
    E9Q529, H3BLC5
    Related
    ENSMUSP00000127076.3, ENSMUST00000166099.3
    Conserved Domains (1) summary
    pfam15476
    Location:76 → 258
    SAP25; Histone deacetylase complex subunit SAP25

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137639735..137641164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1EHW4.1 GenPept UniProtKB/Swiss-Prot:Q1EHW4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools