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Rnf121 ring finger protein 121 [ Mus musculus (house mouse) ]

Gene ID: 75212, updated on 27-Nov-2024

Summary

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Official Symbol
Rnf121provided by MGI
Official Full Name
ring finger protein 121provided by MGI
Primary source
MGI:MGI:1922462
See related
Ensembl:ENSMUSG00000070426 AllianceGenome:MGI:1922462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930544L10Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human RNF121 (ring finger protein 121). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 13.4), large intestine adult (RPKM 13.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf121 in Genome Data Viewer
Location:
7 E2; 7 54.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101668344..101721712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102019137..102072437, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8193 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene interleukin 18 binding protein Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Cheung BB, et al. Commun Biol, 2024 Oct 14. PMID 39402275, Free PMC Article
  2. The E3 ubiquitin ligase RNF121 is a positive regulator of NF-κB activation. Zemirli N, et al. Cell Commun Signal, 2014 Nov 12. PMID 25388546, Free PMC Article
  3. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis.
    Title: Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin ligase Rnf121
NP_001347677.1
NP_083487.2
XP_006508338.1
XP_030098907.1
XP_030098908.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360748.1 → NP_001347677.1  E3 ubiquitin ligase Rnf121 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC150275, AC167240, BE946466
    Conserved Domains (1) summary
    cd16475
    Location:70 → 124
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

  2. NM_029211.3 → NP_083487.2  E3 ubiquitin ligase Rnf121 isoform 1

    See identical proteins and their annotated locations for NP_083487.2

    Status: VALIDATED

    Source sequence(s)
    AC167240, AK159260, BE946466, BY316785
    Consensus CDS
    CCDS21523.1
    UniProtKB/Swiss-Prot
    Q3TXH5, Q8BP06, Q8BSB1, Q8R1Z9, Q9D4X4
    UniProtKB/TrEMBL
    Q3TXY7
    Related
    ENSMUSP00000094396.6, ENSMUST00000096639.12
    Conserved Domains (1) summary
    cd16475
    Location:224 → 278
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101668344..101721712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508275.4 → XP_006508338.1  E3 ubiquitin ligase Rnf121 isoform X1

    See identical proteins and their annotated locations for XP_006508338.1

    UniProtKB/TrEMBL
    Q3TXY7
    Conserved Domains (2) summary
    cd16475
    Location:212 → 266
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
    cl28910
    Location:44 → 200
    MFS; Major Facilitator Superfamily

  2. XM_030243047.2 → XP_030098907.1  E3 ubiquitin ligase Rnf121 isoform X2

    UniProtKB/TrEMBL
    K4DI70, Q3TXY7
    Related
    ENSMUSP00000086453.5, ENSMUST00000089052.11
    Conserved Domains (1) summary
    cd16475
    Location:201 → 255
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

  3. XM_030243048.2 → XP_030098908.1  E3 ubiquitin ligase Rnf121 isoform X3

    Conserved Domains (1) summary
    cd16475
    Location:70 → 124
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1Z9.1 GenPept UniProtKB/Swiss-Prot:Q8R1Z9

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