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Cep128 centrosomal protein 128 [ Mus musculus (house mouse) ]

Gene ID: 75216, updated on 27-Nov-2024

Summary

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Official Symbol
Cep128provided by MGI
Official Full Name
centrosomal protein 128provided by MGI
Primary source
MGI:MGI:1922466
See related
Ensembl:ENSMUSG00000061533 AllianceGenome:MGI:1922466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E230024F20; 4930534B04Rik; 5430424K18Rik
Summary
Acts upstream of or within regulation of gene expression and sperm flagellum assembly. Located in centriole. Orthologous to human CEP128 (centrosomal protein 128). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 30.8), liver E14 (RPKM 3.1) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Cep128 in Genome Data Viewer
Location:
12 D3; 12 44.08 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (90965264..91351207, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (90998490..91384455, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26512 Neighboring gene STARR-seq mESC enhancer starr_32925 Neighboring gene nuclear encoded rRNA 5S 65 Neighboring gene predicted gene, 23195 Neighboring gene STARR-seq mESC enhancer starr_32926 Neighboring gene STARR-seq mESC enhancer starr_32927 Neighboring gene RIKEN cDNA 5430427M07 gene Neighboring gene MOCO sulphurase C-terminal domain containing 2 pseudogene Neighboring gene phosphatidate cytidylyltransferase, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:92497477-92497778 Neighboring gene STARR-seq mESC enhancer starr_32928 Neighboring gene STARR-seq mESC enhancer starr_32929 Neighboring gene predicted gene, 18388 Neighboring gene STARR-positive B cell enhancer ABC_E8495 Neighboring gene thyroid stimulating hormone receptor Neighboring gene phosphoglycerate mutase family member 5 pseudogene Neighboring gene predicted gene, 40541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CEP128 is involved in spermatogenesis in humans and mice. Zhang X, et al. Nat Commun, 2022 Mar 16. PMID 35296684, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of centriolar subdistal appendage IEA
Inferred from Electronic Annotation
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sperm head-tail coupling apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
centrosomal protein of 128 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181815.3 → NP_861536.3  centrosomal protein of 128 kDa

    See identical proteins and their annotated locations for NP_861536.3

    Status: VALIDATED

    Source sequence(s)
    BC079647, CK634985
    Consensus CDS
    CCDS36515.2
    UniProtKB/Swiss-Prot
    Q8BI22
    UniProtKB/TrEMBL
    B7ZNX8
    Related
    ENSMUSP00000115679.2, ENSMUST00000141429.8
    Conserved Domains (1) summary
    pfam07851
    Location:612 → 705
    TMPIT; TMPIT-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    90965264..91351207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244197.3 → XP_011242499.1  centrosomal protein of 128 kDa isoform X6

    See identical proteins and their annotated locations for XP_011242499.1

    Conserved Domains (2) summary
    COG1196
    Location:222 → 602
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:48 → 367
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_030246965.2 → XP_030102825.1  centrosomal protein of 128 kDa isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:406 → 786
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4372
    Location:268 → 491
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    TIGR02169
    Location:694 → 925
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    TIGR03794
    Location:151 → 323
    NHLM_micro_HlyD; NHLM bacteriocin system secretion protein

  3. XM_011244195.4 → XP_011242497.1  centrosomal protein of 128 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:406 → 786
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:222 → 544
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  4. XM_006516324.5 → XP_006516387.1  centrosomal protein of 128 kDa isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:451 → 831
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_017315228.3 → XP_017170717.1  centrosomal protein of 128 kDa isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:295 → 675
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:23 → 795
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_036157636.1 → XP_036013529.1  centrosomal protein of 128 kDa isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:222 → 602
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:48 → 367
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_030246966.2 → XP_030102826.1  centrosomal protein of 128 kDa isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:222 → 602
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:48 → 367
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_011244196.4 → XP_011242498.1  centrosomal protein of 128 kDa isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:451 → 831
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:281 → 612
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    TIGR03794
    Location:151 → 323
    NHLM_micro_HlyD; NHLM bacteriocin system secretion protein

RNA

  1. XR_001780497.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BI22.2 GenPept UniProtKB/Swiss-Prot:Q8BI22

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