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Ppp1r1c protein phosphatase 1, regulatory inhibitor subunit 1C [ Mus musculus (house mouse) ]

Gene ID: 75276, updated on 27-Nov-2024

Summary

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Official Symbol
Ppp1r1cprovided by MGI
Official Full Name
protein phosphatase 1, regulatory inhibitor subunit 1Cprovided by MGI
Primary source
MGI:MGI:1923185
See related
Ensembl:ENSMUSG00000034683 AllianceGenome:MGI:1923185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930565M23Rik; 4930579P15Rik
Summary
Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Is expressed in nervous system. Orthologous to human PPP1R1C (protein phosphatase 1 regulatory inhibitor subunit 1C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Ppp1r1c in Genome Data Viewer
Location:
2 C3; 2 47.58 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (79538124..79648890)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79707780..79818546)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39867 Neighboring gene ITPR interacting domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E2625 Neighboring gene STARR-seq mESC enhancer starr_04937 Neighboring gene STARR-seq mESC enhancer starr_04938 Neighboring gene STARR-seq mESC enhancer starr_04939 Neighboring gene phosphodiesterase 1A, calmodulin-dependent Neighboring gene predicted gene, 54166 Neighboring gene STARR-seq mESC enhancer starr_04941 Neighboring gene STARR-seq mESC enhancer starr_04942 Neighboring gene predicted gene 13674

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis. Chen G, et al. Basic Res Cardiol, 2010 Sep. PMID 20512582, Free PMC Article
  2. Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. Dykes IM, et al. J Neurosci, 2011 Jul 6. PMID 21734270, Free PMC Article
  3. Little skate genome provides insights into genetic programs essential for limb-based locomotion. Yoo D, et al. Elife, 2022 Oct 26. PMID 36288084, Free PMC Article
  4. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Coulpier F, et al. Glia, 2009 Oct. PMID 19243017
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mitochondrial signaling and ERK activation may be involved in the I-1c cardioprotective effects against apoptosis induced by prolonged beta-adrenergic stimulation
    Title: Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290743.1 → NP_001277672.1  protein phosphatase 1 regulatory subunit 1C isoform b

    See identical proteins and their annotated locations for NP_001277672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK051670, AK083940, AK157871
    Consensus CDS
    CCDS71081.1
    UniProtKB/Swiss-Prot
    Q8BKK4
    Related
    ENSMUSP00000107410.3, ENSMUST00000111780.3
    Conserved Domains (1) summary
    pfam05395
    Location:2 → 79
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

  2. NM_001290744.1 → NP_001277673.1  protein phosphatase 1 regulatory subunit 1C isoform c

    See identical proteins and their annotated locations for NP_001277673.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons that result in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK051449, AK051670
    Consensus CDS
    CCDS79810.1
    UniProtKB/Swiss-Prot
    Q8BKK4
    Related
    ENSMUSP00000042784.5, ENSMUST00000040863.11
    Conserved Domains (1) summary
    pfam05395
    Location:2 → 48
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

  3. NM_172420.4 → NP_766008.2  protein phosphatase 1 regulatory subunit 1C isoform a

    See identical proteins and their annotated locations for NP_766008.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK051449, AK051670
    Consensus CDS
    CCDS16171.1
    UniProtKB/Swiss-Prot
    A2AQD1, Q3TZG5, Q8BKK4, Q8BKM4
    Related
    ENSMUSP00000088265.3, ENSMUST00000090760.9
    Conserved Domains (1) summary
    pfam05395
    Location:2 → 87
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

RNA

  1. NR_110979.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and contains an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK051670, AK083940, AK157871
    Related
    ENSMUST00000141978.2

  2. NR_110980.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks four 5' exons but contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK051449, AK051670

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    79538124..79648890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKK4.1 GenPept UniProtKB/Swiss-Prot:Q8BKK4

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