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Izumo2 IZUMO family member 2 [ Mus musculus (house mouse) ]

Gene ID: 75510, updated on 27-Nov-2024

Summary

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Official Symbol
Izumo2provided by MGI
Official Full Name
IZUMO family member 2provided by MGI
Primary source
MGI:MGI:1922760
See related
Ensembl:ENSMUSG00000066500 AllianceGenome:MGI:1922760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700023D19Rik
Summary
Predicted to be located in membrane. Orthologous to human IZUMO2 (IZUMO family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 47.8) See more
Orthologs
human all
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Genomic context

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See Izumo2 in Genome Data Viewer
Location:
7 B3; 7 28.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44358122..44369272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44708698..44719848)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 14 Neighboring gene E1A binding protein p300 pseudogene Neighboring gene RIKEN cDNA 2310016G11 gene Neighboring gene STARR-seq mESC enhancer starr_18813 Neighboring gene zinc finger protein 473 Neighboring gene STARR-positive B cell enhancer ABC_E2823 Neighboring gene vaccinia related kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras(G12D). Huang J, et al. Sci Rep, 2019 Nov 20. PMID 31748650, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
izumo sperm-egg fusion protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368390.1 → NP_001355319.1  izumo sperm-egg fusion protein 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC150895
    UniProtKB/Swiss-Prot
    Q0P5Z2, Q9DA16

  2. NM_029317.2 → NP_083593.1  izumo sperm-egg fusion protein 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC150895, AK006268, BY087754
    Consensus CDS
    CCDS52235.1
    UniProtKB/Swiss-Prot
    Q9DA16
    Related
    ENSMUSP00000082543.3, ENSMUST00000085422.4
    Conserved Domains (1) summary
    pfam15005
    Location:20 → 138
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44358122..44369272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541239.2 → XP_006541302.1  izumo sperm-egg fusion protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15005
    Location:21 → 157
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated

  2. XM_006541240.3 → XP_006541303.1  izumo sperm-egg fusion protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15005
    Location:21 → 131
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated

  3. XM_017312361.2 → XP_017167850.1  izumo sperm-egg fusion protein 2 isoform X5

    Conserved Domains (1) summary
    pfam15005
    Location:21 → 110
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated

  4. XM_006541241.3 → XP_006541304.1  izumo sperm-egg fusion protein 2 isoform X3

    Conserved Domains (1) summary
    pfam15005
    Location:21 → 140
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated

  5. XM_017312360.2 → XP_017167849.1  izumo sperm-egg fusion protein 2 isoform X4

    Conserved Domains (1) summary
    pfam15005
    Location:21 → 110
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated

  6. XM_017312362.3 → XP_017167851.1  izumo sperm-egg fusion protein 2 isoform X6

    Conserved Domains (1) summary
    pfam15005
    Location:21 → 110
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DA16.2 GenPept UniProtKB/Swiss-Prot:Q9DA16

Gene LinkOut

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