U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lin37 lin-37 DREAM MuvB core complex component [ Mus musculus (house mouse) ]

Gene ID: 75660, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Lin37provided by MGI
Official Full Name
lin-37 DREAM MuvB core complex componentprovided by MGI
Primary source
MGI:MGI:1922910
See related
Ensembl:ENSMUSG00000036845 AllianceGenome:MGI:1922910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810054G18Rik
Summary
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of Myb complex. Orthologous to human LIN37 (lin-37 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 17.2), adrenal adult (RPKM 16.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lin37 in Genome Data Viewer
Location:
7 B1; 7 18.58 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30254866..30259289, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30555441..30559721, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene proline and serine rich 3 Neighboring gene STARR-positive B cell enhancer ABC_E9289 Neighboring gene microRNA 9769 Neighboring gene heat shock protein, alpha-crystallin-related, B6 Neighboring gene STARR-positive B cell enhancer ABC_E870 Neighboring gene STARR-positive B cell enhancer ABC_E1338 Neighboring gene STARR-positive B cell enhancer ABC_E4917 Neighboring gene presenilin enhancer gamma secretase subunit Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 Neighboring gene IGF-like family receptor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence. Mages CF, et al. Elife, 2017 Sep 18. PMID 28920576, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thus, Lin37 is an essential component of DREAM complex that cooperates with Rb to induce quiescence.
    Title: The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Myb complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein lin-37 homolog
Names
antolefinin
antolefinine
lin-37 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290569.1 → NP_001277498.1  protein lin-37 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon and intiates translation at a downstream AUG compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC167970, AK007858, BY707863
    Consensus CDS
    CCDS71930.1
    UniProtKB/TrEMBL
    E9Q0Q9, Q91WQ7
    Related
    ENSMUSP00000103799.2, ENSMUST00000108164.8
    Conserved Domains (1) summary
    pfam15306
    Location:72 → 228
    LIN37; LIN37

  2. NM_029377.2 → NP_083653.1  protein lin-37 homolog isoform 1

    See identical proteins and their annotated locations for NP_083653.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK007858
    Consensus CDS
    CCDS21098.1
    UniProtKB/Swiss-Prot
    Q9D8N6
    UniProtKB/TrEMBL
    Q91WQ7
    Related
    ENSMUSP00000048557.5, ENSMUST00000043975.11
    Conserved Domains (1) summary
    pfam15306
    Location:84 → 240
    LIN37; LIN37

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30254866..30259289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250734.4 → XP_011249036.1  protein lin-37 homolog isoform X1

    UniProtKB/TrEMBL
    Q91WQ7
    Conserved Domains (1) summary
    pfam15306
    Location:95 → 251
    LIN37

  2. XM_036153535.1 → XP_036009428.1  protein lin-37 homolog isoform X3

    Conserved Domains (1) summary
    pfam15306
    Location:5 → 161
    LIN37

  3. XM_017312369.3 → XP_017167858.1  protein lin-37 homolog isoform X2

    UniProtKB/TrEMBL
    Q91WQ7
    Conserved Domains (1) summary
    pfam15306
    Location:83 → 239
    LIN37
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8N6.1 GenPept UniProtKB/Swiss-Prot:Q9D8N6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous