Tmem225 transmembrane protein 225 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem225provided by MGI
Official Full Name: transmembrane protein 225provided by MGI
Primary source: MGI:MGI:1922917
See related: Ensembl:ENSMUSG00000040541 AllianceGenome:MGI:1922917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tnen225; 1700030E15Rik
Summary: Enables protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Involved in negative regulation of phosphatase activity. Located in inner acrosomal membrane and outer acrosomal membrane. Orthologous to human TMEM225 (transmembrane protein 225). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 39.4) See more
Orthologs: human all
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Genomic context

Location:: 9 A5.1; 9 21.42 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (40059418..40062176)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (40148122..40150880)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice.
Title: TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice.
TMEM225 is involved in the differentiation and function of spermatozoa through the regulation of PP1gamma2 activity.
Title: TMEM225: a possible protein phosphatase 1γ2 (PP1γ2) regulator localizes to the equatorial segment in mouse spermatozoa.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in inner acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in outer acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transmembrane protein 225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359300.1 → NP_001346229.1 transmembrane protein 225 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AC136021
NM_029379.1 → NP_083655.1 transmembrane protein 225 isoform 1

See identical proteins and their annotated locations for NP_083655.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK006538, BX630292

Consensus CDS

CCDS52774.1

UniProtKB/Swiss-Prot

Q9D9S2

Related

ENSMUSP00000036816.8, ENSMUST00000046333.9