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Bcl2l12 BCL2 like 12 [ Mus musculus (house mouse) ]

Gene ID: 75736, updated on 27-Nov-2024

Summary

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Official Symbol
Bcl2l12provided by MGI
Official Full Name
BCL2 like 12provided by MGI
Primary source
MGI:MGI:1922986
See related
Ensembl:ENSMUSG00000003190 AllianceGenome:MGI:1922986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcl-L12; Bcl2-L12; 2810475P17Rik; 5430429M05Rik
Summary
Enables p53 binding activity. Acts upstream of or within negative regulation of cellular senescence and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; quadriceps femoris muscle; and respiratory system. Orthologous to human BCL2L12 (BCL2 like 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 30.0), limb E14.5 (RPKM 23.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Bcl2l12 in Genome Data Viewer
Location:
7 B3; 7 29.07 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44640646..44647011, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44991222..44997638, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822 Neighboring gene protein arginine N-methyltransferase 1 Neighboring gene predicted gene 15545 Neighboring gene interferon regulatory factor 3 Neighboring gene SR-related CTD-associated factor 1 Neighboring gene microRNA 7054

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulating Bcl2L12 expression in mast cells inhibits food allergy. Zheng PY, et al. Theranostics, 2019. PMID 31410196, Free PMC Article
  2. Bcl2-Like Protein 12 Is Required for the Aberrant T Helper-2 Polarization in the Heart by Enhancing Interleukin-4 Expression and Compromising Apoptotic Machinery in CD4+ T Cells. Chen X, et al. Circulation, 2018 Nov 27. PMID 30571346
  3. Bcl2-like protein 12 plays a critical role in development of airway allergy through inducing aberrant T(H)2 polarization. Liu ZQ, et al. J Allergy Clin Immunol, 2019 Jan. PMID 30227178
  4. Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils. Yang G, et al. Immunol Lett, 2020 Dec. PMID 33132183
  5. IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model. Walker WE, et al. J Leukoc Biol, 2012 Dec. PMID 23048204, Free PMC Article

See all (136) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils.
    Title: Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils.
  2. Regulating Bcl2L12 expression in mast cells inhibits food allergy.
    Title: Regulating Bcl2L12 expression in mast cells inhibits food allergy.
  3. Bcl2-like protein 12 plays a critical role in development of airway allergy through inducing aberrant TH2 polarization.
    Title: Bcl2-like protein 12 plays a critical role in development of airway allergy through inducing aberrant T(H)2 polarization.
  4. Bcl2L12 plays a crucial role in the induction of Th2 polarization and allergic response in the intestine. The Bcl2L12 in CD4(+) T cells may be a potential target for the treatment of food allergy.
    Title: Bcl2L12 plays a critical role in the development of intestinal allergy.
  5. nuclear Bcl2L12 physically and functionally interacts with the p53 tumor suppressor
    Title: Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.
  6. Data show that apoptotic defect in Irf3(-/-)Bcl2l12(-/-) MEFs was rescued by the ectopic expression of Bcl2L12, but not IRF3.
    Title: Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables p53 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cellular senescence IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bcl-2-like protein 12
Names
BCL2-like 12 (proline rich)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403495.1 → NP_001390424.1  bcl-2-like protein 12 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC155806

  2. NM_001403496.1 → NP_001390425.1  bcl-2-like protein 12 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC155806

  3. NM_001403497.1 → NP_001390426.1  bcl-2-like protein 12 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC155806
    UniProtKB/TrEMBL
    Q9D3J3

  4. NM_029410.4 → NP_083686.1  bcl-2-like protein 12 isoform b

    See identical proteins and their annotated locations for NP_083686.1

    Status: VALIDATED

    Source sequence(s)
    AC155806
    Consensus CDS
    CCDS21223.1
    UniProtKB/TrEMBL
    Q9D3J3
    Related
    ENSMUSP00000003290.5, ENSMUST00000003290.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44640646..44647011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541267.5 → XP_006541330.1  bcl-2-like protein 12 isoform X3

    UniProtKB/TrEMBL
    A0A140LIT0
    Conserved Domains (1) summary
    PHA03132
    Location:4 → 158
    PHA03132; thymidine kinase; Provisional

  2. XM_036153537.1 → XP_036009430.1  bcl-2-like protein 12 isoform X2

    UniProtKB/TrEMBL
    A0A140LIT0
    Related
    ENSMUSP00000146945.2, ENSMUST00000207443.2
    Conserved Domains (1) summary
    PHA03132
    Location:4 → 167
    PHA03132; thymidine kinase; Provisional

RNA

  1. XR_003946575.2 RNA Sequence

    Related
    ENSMUST00000208128.2
Nucleotide Protein Strain
Heading Accession and Version

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