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ZBTB25 zinc finger and BTB domain containing 25 [ Homo sapiens (human) ]

Gene ID: 7597, updated on 27-Nov-2024

Summary

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Official Symbol
ZBTB25provided by HGNC
Official Full Name
zinc finger and BTB domain containing 25provided by HGNC
Primary source
HGNC:HGNC:13112
See related
Ensembl:ENSG00000089775 MIM:194541; AllianceGenome:HGNC:13112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KUP; ZNF46; C14orf51
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver (RPKM 4.4), thyroid (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

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See ZBTB25 in Genome Data Viewer
Location:
14q23.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64449106..64505213, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58629558..58712973, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64915824..64971931, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8525 Neighboring gene estrogen receptor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8526 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:64805694-64806376 Neighboring gene testis expressed 21, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8531 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:64858021-64858754 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:64858755-64859488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:64859797-64860574 Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene Sharpr-MPRA regulatory region 9441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5834 Neighboring gene A-kinase anchoring protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8535 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64970928-64971598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5837 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5839 Neighboring gene heat shock protein family A (Hsp70) member 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65039864-65040400 Neighboring gene protein phosphatase 1 regulatory subunit 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc Finger-Containing Cellular Transcription Corepressor ZBTB25 Promotes Influenza Virus RNA Transcription and Is a Target for Zinc Ejector Drugs. Chen SC, et al. J Virol, 2017 Oct 15. PMID 28768860, Free PMC Article
  2. E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro. Lear TB, et al. J Biol Chem, 2023 Dec. PMID 37890782, Free PMC Article
  3. Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. Benita Y, et al. Blood, 2010 Jul 1. PMID 20410506, Free PMC Article
  4. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. Chardin P, et al. Nucleic Acids Res, 1991 Apr 11. PMID 2027750, Free PMC Article
  5. Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy. Madhavan A, et al. mSphere, 2021 Feb 24. PMID 33627504, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro.
    Title: E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro.
  2. Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy.
    Title: Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy.
  3. study demonstrates that ZBTB25 regulates IAV (Influenza A virus) RNA transcription and replication and serves as a promising antiviral target for IAV treatment.
    Title: Zinc Finger-Containing Cellular Transcription Corepressor ZBTB25 Promotes Influenza Virus RNA Transcription and Is a Target for Zinc Ejector Drugs.
  4. ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes.
    Title: Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 25
Names
zinc finger protein 46
zinc finger protein KUP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304507.1 → NP_001291436.1  zinc finger and BTB domain-containing protein 25 isoform a

    See identical proteins and their annotated locations for NP_001291436.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AK098181, AL049869, BC014650, BQ446833, BX479957, DA328137
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    B3KUX6, P24278, Q8IYH9
    Related
    ENSP00000378204.1, ENST00000394715.1
    Conserved Domains (3) summary
    sd00019
    Location:240 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain

  2. NM_001304508.1 → NP_001291437.1  zinc finger and BTB domain-containing protein 25 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL049869, BC014650
    Consensus CDS
    CCDS76689.1
    UniProtKB/TrEMBL
    G3V2K3
    Related
    ENSP00000450718.1, ENST00000555220.5
    Conserved Domains (1) summary
    pfam00651
    Location:14 → 60
    BTB; BTB/POZ domain

  3. NM_001354682.2 → NP_001341611.1  zinc finger and BTB domain-containing protein 25 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (c).
    Source sequence(s)
    AL049869, AL122035
    Conserved Domains (3) summary
    sd00019
    Location:279 → 299
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279 → 299
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:53 → 153
    BTB; BTB/POZ domain

  4. NM_001354683.2 → NP_001341612.1  zinc finger and BTB domain-containing protein 25 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL049869
    Conserved Domains (3) summary
    sd00019
    Location:240 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain

  5. NM_001354684.2 → NP_001341613.1  zinc finger and BTB domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    B3KUX6, P24278, Q8IYH9
    Conserved Domains (3) summary
    sd00019
    Location:240 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain

  6. NM_001354685.2 → NP_001341614.1  zinc finger and BTB domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    B3KUX6, P24278, Q8IYH9
    Conserved Domains (3) summary
    sd00019
    Location:240 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain

  7. NM_001354686.2 → NP_001341615.1  zinc finger and BTB domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    B3KUX6, P24278, Q8IYH9
    Conserved Domains (3) summary
    sd00019
    Location:240 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain

  8. NM_001354687.2 → NP_001341616.1  zinc finger and BTB domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    B3KUX6, P24278, Q8IYH9
    Conserved Domains (3) summary
    sd00019
    Location:240 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain

  9. NM_006977.5 → NP_008908.2  zinc finger and BTB domain-containing protein 25 isoform a

    See identical proteins and their annotated locations for NP_008908.2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035, BC035804, BQ446833, BX479957, DA328137
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    B3KUX6, P24278, Q8IYH9
    Related
    ENSP00000476746.1, ENST00000608382.6
    Conserved Domains (3) summary
    sd00019
    Location:240 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    64449106..64505213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431770.1 → XP_047287726.1  zinc finger and BTB domain-containing protein 25 isoform X1

RNA

  1. XR_943522.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    58629558..58712973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376710.1 → XP_054232685.1  zinc finger and BTB domain-containing protein 25 isoform X3

  2. XM_054376709.1 → XP_054232684.1  zinc finger and BTB domain-containing protein 25 isoform X1

  3. XM_054376708.1 → XP_054232683.1  zinc finger and BTB domain-containing protein 25 isoform X2

RNA

  1. XR_008488894.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24278.2 GenPept UniProtKB/Swiss-Prot:P24278

Gene LinkOut

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