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Adhfe1 alcohol dehydrogenase, iron containing, 1 [ Mus musculus (house mouse) ]

Gene ID: 76187, updated on 27-Nov-2024

Summary

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Official Symbol
Adhfe1provided by MGI
Official Full Name
alcohol dehydrogenase, iron containing, 1provided by MGI
Primary source
MGI:MGI:1923437
See related
Ensembl:ENSMUSG00000025911 AllianceGenome:MGI:1923437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HOT; Adh8; 6330565B14Rik
Summary
Predicted to enable alcohol dehydrogenase (NAD+) activity and hydroxyacid-oxoacid transhydrogenase activity. Predicted to be involved in glutamate catabolic process via 2-hydroxyglutarate. Located in mitochondrion. Is expressed in several structures, including brain; cranium; genitourinary system; sensory organ; and spinal cord. Orthologous to human ADHFE1 (alcohol dehydrogenase iron containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 62.9), subcutaneous fat pad adult (RPKM 31.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Adhfe1 in Genome Data Viewer
Location:
1 A2; 1 2.08 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (9618173..9648195)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (9547948..9577970)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cytochrome b5 reductase 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00164 Neighboring gene STARR-positive B cell enhancer ABC_E404 Neighboring gene RIKEN cDNA 2610203C22 gene Neighboring gene ribosome biogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4303 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00166 Neighboring gene vexin Neighboring gene STARR-seq mESC enhancer starr_00167 Neighboring gene VISTA enhancer mm1546 Neighboring gene myeloblastosis oncogene-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differentiation-dependent expression of Adhfe1 in adipogenesis. Kim JY, et al. Arch Biochem Biophys, 2007 Aug 1. PMID 17559793, Free PMC Article
  2. Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Keng VW, et al. Nat Methods, 2005 Oct. PMID 16179923
  3. Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Nabeshima R, et al. Elife, 2018 Aug 2. PMID 30070635, Free PMC Article
  4. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adhfe1 is a novel alcohol dehydrogenase with mitochondrial localization
    Title: Differentiation-dependent expression of Adhfe1 in adipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Transposon induced (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alcohol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacid-oxoacid transhydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydroxyacid-oxoacid transhydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutamate catabolic process via 2-hydroxyglutarate ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamate catabolic process via 2-hydroxyglutarate ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hydroxyacid-oxoacid transhydrogenase, mitochondrial
Names
Fe-containing alcohol dehydrogenase 1
alcohol dehydrogenase 8
alcohol dehydrogenase iron-containing protein 1
NP_001344305.1
NP_001344306.1
NP_001344307.1
NP_780445.1
XP_006495649.1
XP_036010127.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357376.1 → NP_001344305.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC103620
    UniProtKB/TrEMBL
    A0A087WRE7
    Conserved Domains (1) summary
    cd08190
    Location:3 → 416
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  2. NM_001357377.1 → NP_001344306.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC103620
    UniProtKB/TrEMBL
    A0A087WRE7
    Conserved Domains (1) summary
    cd08190
    Location:3 → 416
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  3. NM_001357378.1 → NP_001344307.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC103620
    UniProtKB/TrEMBL
    A0A087WRE7
    Conserved Domains (1) summary
    cd08190
    Location:1 → 394
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  4. NM_175236.5 → NP_780445.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_780445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC103620, AK038853, AW494922
    Consensus CDS
    CCDS14812.1
    UniProtKB/Swiss-Prot
    Q78SV3, Q8BYP0, Q8R0N6
    UniProtKB/TrEMBL
    A0A087WRE7
    Related
    ENSMUSP00000116627.2, ENSMUST00000144177.8
    Conserved Domains (1) summary
    cd08190
    Location:49 → 462
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    9618173..9648195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154234.1 → XP_036010127.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A087WRE7
    Conserved Domains (1) summary
    cd08190
    Location:17 → 430
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  2. XM_006495586.4 → XP_006495649.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006495649.1

    UniProtKB/TrEMBL
    A0A087WRE7
    Conserved Domains (1) summary
    cd08190
    Location:3 → 416
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0N6.2 GenPept UniProtKB/Swiss-Prot:Q8R0N6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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