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Tgds TDP-glucose 4,6-dehydratase [ Mus musculus (house mouse) ]

Gene ID: 76355, updated on 27-Nov-2024

Summary

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Official Symbol
Tgdsprovided by MGI
Official Full Name
TDP-glucose 4,6-dehydrataseprovided by MGI
Primary source
MGI:MGI:1923605
See related
Ensembl:ENSMUSG00000022130 AllianceGenome:MGI:1923605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610017J16Rik; 2610025M23Rik
Summary
Predicted to enable dTDP-glucose 4,6-dehydratase activity. Predicted to be involved in nucleotide-sugar metabolic process. Is expressed in several structures, including alimentary system; cranium; eye; integumental system; and telencephalon. Human ortholog(s) of this gene implicated in Catel Manzke syndrome. Orthologous to human TGDS (TDP-glucose 4,6-dehydratase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 12.4), limb E14.5 (RPKM 9.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tgds in Genome Data Viewer
Location:
14 E4; 14 61.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (118349323..118370177, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118111911..118132765, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dopachrome tautomerase Neighboring gene STARR-positive B cell enhancer ABC_E7351 Neighboring gene nuclear encoded tRNA pheylalanine 5 (anticodon GAA) Neighboring gene predicted gene, 31633 Neighboring gene STARR-seq mESC enhancer starr_37634 Neighboring gene STARR-positive B cell enhancer ABC_E7352 Neighboring gene G protein-coupled receptor 180 Neighboring gene predicted gene 4674

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice. Geister KA, et al. G3 (Bethesda), 2018 Feb 2. PMID 29208648, Free PMC Article
  2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dTDP-glucose 4,6-dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dTDP-glucose 4,6-dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in nucleotide-sugar metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
dTDP-D-glucose 4,6-dehydratase
NP_083854.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029578.3 → NP_083854.3  dTDP-D-glucose 4,6-dehydratase

    See identical proteins and their annotated locations for NP_083854.3

    Status: VALIDATED

    Source sequence(s)
    AK165685, AK165955, BY710811, CB953719
    Consensus CDS
    CCDS27332.1
    UniProtKB/Swiss-Prot
    Q3U4A6, Q8VDR7
    UniProtKB/TrEMBL
    Q9D0D1
    Related
    ENSMUSP00000022727.9, ENSMUST00000022727.10
    Conserved Domains (2) summary
    cd05246
    Location:18 → 336
    dTDP_GD_SDR_e; dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs
    COG1088
    Location:18 → 340
    RfbB; dTDP-D-glucose 4,6-dehydratase [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    118349323..118370177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDR7.2 GenPept UniProtKB/Swiss-Prot:Q8VDR7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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