Aoc1 amine oxidase, copper-containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aoc1provided by MGI
Official Full Name: amine oxidase, copper-containing 1provided by MGI
Primary source: MGI:MGI:1923757
See related: Ensembl:ENSMUSG00000029811 AllianceGenome:MGI:1923757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DAO; Abp1; 1600012D06Rik
Summary: Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in putrescine metabolic process. Predicted to be located in bicellular tight junction and extracellular exosome. Predicted to be active in plasma membrane. Is expressed in mesonephros and urinary system. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 196.7), small intestine adult (RPKM 189.0) and 2 other tissues See more
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Genomic context

Location:: 6 B2.3; 6 23.78 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (48872189..48886122)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (48895255..48909188)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest that WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis
Title: Amine oxidase copper-containing 1 (AOC1) is a downstream target gene of the Wilms tumor protein, WT1, during kidney development.
F-actin-anchored Cobl/Abp1 complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells in the cerebellar cortex.
Title: The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.
study identifies a role for the actin binding protein mAbp1 in the formation of podosome rosettes and regulation of invasive cell migration
Title: Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts.
Abp1 may be essential for mouse embryo implantation and decidualization.
Title: Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Mit313 (e-PCR), detects polymorphism
- UniSTS:130866

Abp1 (e-PCR), detects polymorphism
- UniSTS:546619

NoName (e-PCR)
- UniSTS:235435

NoName (e-PCR)
- UniSTS:235437

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables diamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables diamine oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables histamine oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables primary methylamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables primary methylamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables putrescine oxidase activity	ISO Inferred from Sequence Orthology more info
enables putrescine oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables quinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in putrescine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in putrescine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: diamine oxidase [copper-containing]; amiloride-sensitive amine oxidase [copper-containing]

Names: ABP; amiloride binding protein 1 (amine oxidase, copper-containing); amiloride-binding protein 1; amiloride-sensitive amine oxidase; amine oxidase copper domain-containing protein 1; diamine oxidase; histaminase

NP_001155093.1

EC 1.4.3.22

NP_001155094.1

EC 1.4.3.22

NP_083914.2

EC 1.4.3.22

XP_030111522.1

EC 1.4.3.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161621.1 → NP_001155093.1 diamine oxidase [copper-containing] precursor

See identical proteins and their annotated locations for NP_001155093.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AC159547, AK146078

Consensus CDS

CCDS51767.1

UniProtKB/TrEMBL

E9PYN9, Q3UKB9

Related

ENSMUSP00000124085.2, ENSMUST00000162948.7

Conserved Domains (3) summary

pfam02727
Location:44 → 129

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:146 → 245

Cu_amine_oxidN3; Copper amine oxidase, N3 domain

pfam01179
Location:305 → 717

Cu_amine_oxid; Copper amine oxidase, enzyme domain
NM_001161622.1 → NP_001155094.1 diamine oxidase [copper-containing] precursor

See identical proteins and their annotated locations for NP_001155094.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). All three variants encode the same protein.

Source sequence(s)

AC159547, AK146078, BB868807

Consensus CDS

CCDS51767.1

UniProtKB/TrEMBL

E9PYN9, Q3UKB9

Related

ENSMUSP00000128816.2, ENSMUST00000167529.3

Conserved Domains (3) summary

pfam02727
Location:44 → 129

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:146 → 245

Cu_amine_oxidN3; Copper amine oxidase, N3 domain

pfam01179
Location:305 → 717

Cu_amine_oxid; Copper amine oxidase, enzyme domain
NM_029638.2 → NP_083914.2 diamine oxidase [copper-containing] precursor

See identical proteins and their annotated locations for NP_083914.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant (1). All three variants encode the same protein.

Source sequence(s)

AC159547, AK146078, BY131896

Consensus CDS

CCDS51767.1

UniProtKB/TrEMBL

E9PYN9, Q3UKB9

Related

ENSMUSP00000031835.8, ENSMUST00000031835.14

Conserved Domains (3) summary

pfam02727
Location:44 → 129

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:146 → 245

Cu_amine_oxidN3; Copper amine oxidase, N3 domain

pfam01179
Location:305 → 717

Cu_amine_oxid; Copper amine oxidase, enzyme domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

48872189..48886122

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255662.1 → XP_030111522.1 amiloride-sensitive amine oxidase [copper-containing] isoform X1

UniProtKB/TrEMBL

E9PYN9, Q3UKB9

Conserved Domains (3) summary

pfam02727
Location:44 → 129

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:146 → 245

Cu_amine_oxidN3; Copper amine oxidase, N3 domain

pfam01179
Location:305 → 717

Cu_amine_oxid; Copper amine oxidase, enzyme domain