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Ccdc6 coiled-coil domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 76551, updated on 27-Nov-2024

Summary

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Official Symbol
Ccdc6provided by MGI
Official Full Name
coiled-coil domain containing 6provided by MGI
Primary source
MGI:MGI:1923801
See related
Ensembl:ENSMUSG00000048701 AllianceGenome:MGI:1923801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810012H18Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be located in cytosol. Orthologous to human CCDC6 (coiled-coil domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 13.7), bladder adult (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc6 in Genome Data Viewer
Location:
10 B5.3; 10 36.68 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (69932709..70029030)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (70096878..70193200)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ankyrin 3, epithelial Neighboring gene STARR-seq mESC enhancer starr_27063 Neighboring gene predicted gene, 33416 Neighboring gene predicted gene, 33361 Neighboring gene STARR-seq mESC enhancer starr_27068 Neighboring gene STARR-seq mESC enhancer starr_27069 Neighboring gene STARR-positive B cell enhancer ABC_E5146 Neighboring gene STARR-seq mESC enhancer starr_27073 Neighboring gene predicted gene, 51771 Neighboring gene uncharacterized LOC118567787 Neighboring gene myoregulin Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity. Leone V, et al. Oncotarget, 2015 Jun 20. PMID 25970781, Free PMC Article
  2. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
  3. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111121.2 → NP_001104591.1  coiled-coil domain-containing protein 6

    See identical proteins and their annotated locations for NP_001104591.1

    Status: VALIDATED

    Source sequence(s)
    AC132435
    Consensus CDS
    CCDS48591.1
    UniProtKB/Swiss-Prot
    D3YZP9
    Related
    ENSMUSP00000123374.2, ENSMUST00000147545.8
    Conserved Domains (1) summary
    pfam09755
    Location:45 → 330
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    69932709..70029030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514276.4 → XP_006514339.1  coiled-coil domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    pfam09755
    Location:45 → 330
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)

  2. XM_006514277.4 → XP_006514340.1  coiled-coil domain-containing protein 6 isoform X2

    Conserved Domains (1) summary
    pfam09755
    Location:13 → 248
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YZP9.1 GenPept UniProtKB/Swiss-Prot:D3YZP9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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