Alpi alkaline phosphatase, intestinal [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alpiprovided by MGI
Official Full Name: alkaline phosphatase, intestinalprovided by MGI
Primary source: MGI:MGI:1924018
See related: Ensembl:ENSMUSG00000079440 AllianceGenome:MGI:1924018
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Akp6; gIAP; 2010001C14Rik
Summary: Predicted to enable several functions, including alkaline phosphatase activity; metal ion binding activity; and protein homodimerization activity. Acts upstream of or within cellular response to BMP stimulus. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in intestine; palatal shelf mesenchyme; and testis. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 2234.3), small intestine adult (RPKM 1574.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 44.05 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87025724..87029328, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (87098002..87101606, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency.
Title: Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency.
Intestinal alkaline phosphatase is a major regulator of gut mucosal permeability and appears to work at least partly through improving tight junction protein levels and localization.
Title: Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.
It is concluded that CD36 exists in its phosphorylated and dephosphorylated states in mouse enterocytes and that pCD36 is a substrate of global intestinal alkaline phosphatase (gIAP).
Title: Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet.
Suggest role for lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.
Title: Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to BMP stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in coenzyme A catabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: intestinal alkaline phosphatase

Names: alkaline phosphatase 6

NP_001074551.1

EC 3.1.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.