grin1a glutamate receptor, ionotropic, N-methyl D-aspartate 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grin1aprovided by ZNC
Official Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051202-1
See related: Ensembl:ENSDARG00000027828 AllianceGenome:ZFIN:ZDB-GENE-051202-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NMDAR1.1; zgc:152678
Summary: Enables ligand-gated monoatomic ion channel activity. Involved in calcium ion transmembrane transport. Predicted to be located in postsynaptic membrane. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (11468601..11501324)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (11375917..11410343)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	IPI Inferred from Physical Interaction more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 1a

Names: NMDA receptor glycine-binding subunit NR1.1; round spermatid basic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076714.2 → NP_001070182.2 glutamate receptor ionotropic, NMDA 1a precursor

Status: VALIDATED

Source sequence(s)

BX005379

UniProtKB/TrEMBL

A0A8M1NB21, A0A8M2B7Z7, F1R366

Related

ENSDARP00000093144.4, ENSDART00000102368.5

Conserved Domains (5) summary

cd06379
Location:5 → 401

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:413 → 815

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:577 → 840

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 372

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:851 → 879

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit