U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cenpe centromere protein E [ Danio rerio (zebrafish) ]

Gene ID: 767754, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
cenpeprovided by ZNC
Official Full Name
centromere protein Eprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-860
See related
Ensembl:ENSDARG00000063385 AllianceGenome:ZFIN:ZDB-GENE-060929-860
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc06a10; zgc:152925
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule-based movement and mitotic cell cycle. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cenpe in Genome Data Viewer
Location:
chromosome: 1
Exon count:
58
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (260012..296057)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (264833..300878)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transcription factor Dp-1, b Neighboring gene G protein-coupled receptor kinase 1 a Neighboring gene uncharacterized LOC103911743 Neighboring gene growth arrest-specific 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Kinesin-7 CENP-E regulates cell division, gastrulation and organogenesis in development. Yu KW, et al. Eur J Cell Biol, 2020 Aug. PMID 32800279
  2. Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Lin X, et al. Life (Basel), 2022 Sep 16. PMID 36143477, Free PMC Article
  3. Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Chen J, et al. Sci China Life Sci, 2021 Dec. PMID 33751369
  4. Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Castro LF, et al. Proc Biol Sci, 2014 Jan 22. PMID 24307675, Free PMC Article
  5. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC152925

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
centromere-associated protein E

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327759.1 → NP_001314688.1  centromere-associated protein E

    Status: PROVISIONAL

    Source sequence(s)
    CU179747
    UniProtKB/TrEMBL
    A0A8M1P2Y6, A0A8M2BFG4, E7F2U4
    Related
    ENSDARP00000099552.3, ENSDART00000111806.5
    Conserved Domains (7) summary
    smart00129
    Location:6 → 343
    KISc; Kinesin motor, catalytic domain. ATPase
    TIGR02168
    Location:1468 → 2193
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01374
    Location:6 → 337
    KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
    pfam01576
    Location:801 → 1826
    Myosin_tail_1; Myosin tail
    pfam08172
    Location:984 → 1100
    CASP_C; CASP C terminal
    cl14813
    Location:1935 → 2053
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    cl19219
    Location:1430 → 1517
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    260012..296057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168005.5 → XP_005168062.1  centromere-associated protein E isoform X1

    UniProtKB/TrEMBL
    A0A8M2BFG2, A0A8M2BFG4
    Conserved Domains (7) summary
    smart00129
    Location:6 → 343
    KISc; Kinesin motor, catalytic domain. ATPase
    TIGR02168
    Location:1468 → 2193
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01374
    Location:6 → 337
    KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
    pfam01576
    Location:801 → 1826
    Myosin_tail_1; Myosin tail
    pfam08172
    Location:984 → 1100
    CASP_C; CASP C terminal
    cl14813
    Location:1935 → 2053
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    cl19219
    Location:1430 → 1517
    DUF342; Protein of unknown function (DUF342)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001076721.1: Suppressed sequence

    Description
    NM_001076721.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools