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Nubpl nucleotide binding protein-like [ Mus musculus (house mouse) ]

Gene ID: 76826, updated on 27-Nov-2024

Summary

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Official Symbol
Nubplprovided by MGI
Official Full Name
nucleotide binding protein-likeprovided by MGI
Primary source
MGI:MGI:1924076
See related
Ensembl:ENSMUSG00000035142 AllianceGenome:MGI:1924076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410170E07Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 21. Orthologous to human NUBPL (NUBP iron-sulfur cluster assembly factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 4.3), kidney adult (RPKM 3.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Nubpl in Genome Data Viewer
Location:
12 C1; 12 22.11 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (52144529..52357753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (52097746..52310970)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 33 Neighboring gene CD79A antigen (immunoglobulin-associated alpha) pseudogene Neighboring gene VISTA enhancer mm292 Neighboring gene STARR-seq mESC enhancer starr_32119 Neighboring gene STARR-seq mESC enhancer starr_32121 Neighboring gene STARR-seq mESC enhancer starr_32122 Neighboring gene STARR-seq mESC enhancer starr_32123 Neighboring gene predicted gene, 40423 Neighboring gene STARR-seq mESC enhancer starr_32127 Neighboring gene predicted gene, 35071

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Early embryonic lethality in complex I associated p.L104P Nubpl mutant mice. Cheng C, et al. Orphanet J Rare Dis, 2022 Oct 24. PMID 36280881, Free PMC Article
  2. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
  3. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent FeS chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
iron-sulfur cluster transfer protein NUBPL
Names
iron-sulfur protein NUBPL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029760.2 → NP_084036.2  iron-sulfur cluster transfer protein NUBPL precursor

    See identical proteins and their annotated locations for NP_084036.2

    Status: VALIDATED

    Source sequence(s)
    AI118524, BC062175, BY160608
    Consensus CDS
    CCDS36442.2
    UniProtKB/Swiss-Prot
    Q6P6K2, Q9CWD8
    UniProtKB/TrEMBL
    Q3URR8
    Related
    ENSMUSP00000044292.10, ENSMUST00000040090.16
    Conserved Domains (2) summary
    COG0489
    Location:17 → 284
    Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
    pfam10609
    Location:65 → 311
    ParA; NUBPL iron-transfer P-loop NTPase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    52144529..52357753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516363.3 → XP_006516426.1  iron-sulfur cluster transfer protein NUBPL isoform X2

    Conserved Domains (1) summary
    pfam10609
    Location:21 → 236
    ParA; NUBPL iron-transfer P-loop NTPase

  2. XM_006516362.3 → XP_006516425.1  iron-sulfur cluster transfer protein NUBPL isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1 → 128
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWD8.2 GenPept UniProtKB/Swiss-Prot:Q9CWD8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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