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Ccdc116 coiled-coil domain containing 116 [ Mus musculus (house mouse) ]

Gene ID: 76872, updated on 27-Nov-2024

Summary

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Official Symbol
Ccdc116provided by MGI
Official Full Name
coiled-coil domain containing 116provided by MGI
Primary source
MGI:MGI:1924122
See related
Ensembl:ENSMUSG00000022768 AllianceGenome:MGI:1924122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930432J16Rik
Summary
Predicted to be located in cytoplasm. Predicted to be active in centrosome. Is expressed in ductus deferens; epididymis; ileum; and testis. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human CCDC116 (coiled-coil domain containing 116). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 40.8), duodenum adult (RPKM 4.7) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc116 in Genome Data Viewer
Location:
16 A3; 16 10.62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16956928..16965459, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17139064..17147802, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E214 Neighboring gene stromal cell-derived factor 2-like 1 Neighboring gene Rps20 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4157 Neighboring gene YdjC homolog (bacterial) Neighboring gene ubiquitin-conjugating enzyme E2L 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17201546-17201655 Neighboring gene predicted gene, 22129

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
  2. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 116

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306169.1 → NP_001293098.1  coiled-coil domain-containing protein 116 isoform 1

    See identical proteins and their annotated locations for NP_001293098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longer transcript. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    BC050881, BC057359
    Consensus CDS
    CCDS27995.1
    UniProtKB/Swiss-Prot
    Q6PFY7, Q80X53, Q9D5J4
    Related
    ENSMUSP00000023452.8, ENSMUST00000023452.16
    Conserved Domains (1) summary
    pfam15774
    Location:24 → 408
    DUF4702; Domain of unknown function (DUF4702)

  2. NM_001373948.1 → NP_001360877.1  coiled-coil domain-containing protein 116 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154667
    Consensus CDS
    CCDS88887.1
    UniProtKB/TrEMBL
    A0A338P7I8
    Related
    ENSMUSP00000156301.2, ENSMUST00000232540.2
    Conserved Domains (1) summary
    pfam15774
    Location:18 → 408
    DUF4702; Domain of unknown function (DUF4702)

  3. NM_029779.2 → NP_084055.2  coiled-coil domain-containing protein 116 isoform 1

    See identical proteins and their annotated locations for NP_084055.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK015290, BC057359
    Consensus CDS
    CCDS27995.1
    UniProtKB/Swiss-Prot
    Q6PFY7, Q80X53, Q9D5J4
    Related
    ENSMUSP00000155923.2, ENSMUST00000232033.2
    Conserved Domains (1) summary
    pfam15774
    Location:24 → 408
    DUF4702; Domain of unknown function (DUF4702)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16956928..16965459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317158.3 → XP_017172647.1  coiled-coil domain-containing protein 116 isoform X2

    UniProtKB/Swiss-Prot
    Q6PFY7, Q80X53, Q9D5J4
    Conserved Domains (1) summary
    pfam15774
    Location:24 → 408
    DUF4702; Domain of unknown function (DUF4702)

  2. XM_006522710.2 → XP_006522773.1  coiled-coil domain-containing protein 116 isoform X1

    See identical proteins and their annotated locations for XP_006522773.1

    UniProtKB/TrEMBL
    A0A338P7I8
    Conserved Domains (1) summary
    pfam15774
    Location:18 → 408
    DUF4702; Domain of unknown function (DUF4702)

  3. XM_006522709.5 → XP_006522772.1  coiled-coil domain-containing protein 116 isoform X1

    See identical proteins and their annotated locations for XP_006522772.1

    UniProtKB/TrEMBL
    A0A338P7I8
    Conserved Domains (1) summary
    pfam15774
    Location:18 → 408
    DUF4702; Domain of unknown function (DUF4702)

  4. XM_036160177.1 → XP_036016070.1  coiled-coil domain-containing protein 116 isoform X1

    UniProtKB/TrEMBL
    A0A338P7I8
    Conserved Domains (1) summary
    pfam15774
    Location:18 → 408
    DUF4702; Domain of unknown function (DUF4702)

  5. XM_006522708.5 → XP_006522771.1  coiled-coil domain-containing protein 116 isoform X1

    See identical proteins and their annotated locations for XP_006522771.1

    UniProtKB/TrEMBL
    A0A338P7I8
    Conserved Domains (1) summary
    pfam15774
    Location:18 → 408
    DUF4702; Domain of unknown function (DUF4702)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001164606.1: Suppressed sequence

    Description
    NM_001164606.1: This RefSeq was permanently suppressed because there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X53.1 GenPept UniProtKB/Swiss-Prot:Q80X53

Gene LinkOut

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