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Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 76987, updated on 27-Nov-2024

Summary

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Official Symbol
Hdhd2provided by MGI
Official Full Name
haloacid dehalogenase-like hydrolase domain containing 2provided by MGI
Primary source
MGI:MGI:1924237
See related
Ensembl:ENSMUSG00000025421 AllianceGenome:MGI:1924237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610039H12Rik; 3110052N05Rik
Summary
Predicted to enable enzyme binding activity and phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be active in cytoplasm. Is expressed in cerebellum and cerebral cortex ventricular layer. Orthologous to human HDHD2 (haloacid dehalogenase like hydrolase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.2), frontal lobe adult (RPKM 7.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hdhd2 in Genome Data Viewer
Location:
18 E3; 18 51.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77031775..77059867)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (76944115..76972171)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45102 Neighboring gene predicted gene, 32058 Neighboring gene STARR-seq mESC enhancer starr_45103 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene predicted gene, 53183 Neighboring gene katanin p60 subunit A-like 2 Neighboring gene STARR-seq mESC enhancer starr_45107 Neighboring gene STARR-positive B cell enhancer mm9_chr18:77285922-77286223 Neighboring gene RIKEN cDNA 4930520E11 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Wang B, et al. Development, 2011 Oct. PMID 21937600, Free PMC Article
  2. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
  3. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
  4. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Transposon induced (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
haloacid dehalogenase-like hydrolase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039201.2 → NP_001034290.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001034290.1

    Status: VALIDATED

    Source sequence(s)
    AC132608
    Consensus CDS
    CCDS37863.1
    UniProtKB/Swiss-Prot
    Q3U8M0, Q3UGR5, Q6PEB2, Q9CXN1, Q9DCF2
    Related
    ENSMUSP00000116243.2, ENSMUST00000148955.3
    Conserved Domains (1) summary
    cd07509
    Location:8 → 255
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

  2. NM_001039202.1 → NP_001034291.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001034291.1

    Status: VALIDATED

    Source sequence(s)
    AK152259, BY069367
    Consensus CDS
    CCDS37864.1
    UniProtKB/Swiss-Prot
    Q3UGR5
    Related
    ENSMUSP00000095128.5, ENSMUST00000097521.12
    Conserved Domains (1) summary
    pfam13344
    Location:10 → 86
    Hydrolase_6; Haloacid dehalogenase-like hydrolase

  3. NM_001361227.1 → NP_001348156.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132608
    Consensus CDS
    CCDS37863.1
    UniProtKB/Swiss-Prot
    Q3U8M0, Q3UGR5, Q6PEB2, Q9CXN1, Q9DCF2
    Related
    ENSMUSP00000114212.2, ENSMUST00000150990.9
    Conserved Domains (1) summary
    cd07509
    Location:8 → 255
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

  4. NM_029826.2 → NP_084102.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_084102.1

    Status: VALIDATED

    Source sequence(s)
    AC132608, AK137285, BY069367
    Consensus CDS
    CCDS37863.1
    UniProtKB/Swiss-Prot
    Q3U8M0, Q3UGR5, Q6PEB2, Q9CXN1, Q9DCF2
    Related
    ENSMUSP00000095129.4, ENSMUST00000097522.11
    Conserved Domains (1) summary
    cd07509
    Location:8 → 255
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77031775..77059867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161307.1 → XP_036017200.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    cl21460
    Location:8 → 133
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. XM_036161308.1 → XP_036017201.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    cl21460
    Location:8 → 133
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UGR5.2 GenPept UniProtKB/Swiss-Prot:Q3UGR5

Gene LinkOut

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