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LK403_RS24705 steroid 3-ketoacyl-CoA thiolase [ Mycobacterium intracellulare ]

Gene ID: 77303989, updated on 10-Dec-2024

Summary

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Gene symbol
LK403_RS24705
Gene description
steroid 3-ketoacyl-CoA thiolase
Locus tag
LK403_RS24705
Gene type
protein coding
Organism
Mycobacterium intracellulare (strain: FDAARGOS_1564, culture-collection: DSM:44655)
Lineage
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium avium complex (MAC)
Old locus tag
LK403_24705
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Genomic context

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NZ_CP085945.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase FadE29 Neighboring gene acyl-CoA dehydrogenase family protein Neighboring gene cytochrome P450 Neighboring gene hypothetical protein Neighboring gene nitroreductase family deazaflavin-dependent oxidoreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NZ_CP085945.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch. Lu R, et al. ACS Infect Dis, 2017 Sep 8. PMID 28786661, Free PMC Article
  2. FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis. Schaefer CM, et al. Structure, 2015 Jan 6. PMID 25482540, Free PMC Article
  3. A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol. Nesbitt NM, et al. Infect Immun, 2010 Jan. PMID 19822655, Free PMC Article

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
steroid 3-ketoacyl-CoA thiolase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NZ_CP085945.1 Reference assembly

    Range
    5290066..5291229
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_014381753.1 MULTISPECIES: steroid 3-ketoacyl-CoA thiolase [Mycobacterium]

    UniProtKB/TrEMBL
    A0AAE5J0Z5
    Conserved Domains (1) summary
    PRK07850
    Location:1 → 387
    PRK07850; steroid 3-ketoacyl-CoA thiolase
Nucleotide Protein
Heading Accession and Version