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Kidins220 kinase D-interacting substrate 220 [ Mus musculus (house mouse) ]

Gene ID: 77480, updated on 27-Nov-2024

Summary

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Official Symbol
Kidins220provided by MGI
Official Full Name
kinase D-interacting substrate 220provided by MGI
Primary source
MGI:MGI:1924730
See related
Ensembl:ENSMUSG00000036333 AllianceGenome:MGI:1924730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1250; 3110039L19Rik; C330002I19Rik
Summary
Predicted to enable PDZ domain binding activity; protein kinase binding activity; and protein kinase regulator activity. Acts upstream of or within dendrite morphogenesis and in utero embryonic development. Predicted to be located in late endosome. Predicted to be part of protein-containing complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human KIDINS220 (kinase D interacting substrate 220). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 54.8), whole brain E14.5 (RPKM 42.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Kidins220 in Genome Data Viewer
Location:
12 A1.3; 12 8.54 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (25024909..25113151)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (24974903..25063152)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060N12 gene Neighboring gene STARR-seq mESC enhancer starr_31760 Neighboring gene membrane bound O-acyltransferase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E5324 Neighboring gene predicted gene, 36236 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25695412-25695595 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25777982-25778091 Neighboring gene STARR-positive B cell enhancer mm9_chr12:25780927-25781228 Neighboring gene inhibitor of DNA binding 2 Neighboring gene predicted gene, 17746

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis. Del Puerto A, et al. Cell Death Dis, 2023 Aug 4. PMID 37542079, Free PMC Article
  2. A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Duffy AM, et al. Exp Neurol, 2011 Jun. PMID 21419124, Free PMC Article
  3. Kidins220/ARMS is a novel modulator of short-term synaptic plasticity in hippocampal GABAergic neurons. Scholz-Starke J, et al. PLoS One, 2012. PMID 22563401, Free PMC Article
  4. Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development. Higuero AM, et al. J Biol Chem, 2010 Jan 8. PMID 19903810, Free PMC Article
  5. Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development. Chen Y, et al. J Neurosci, 2012 Jun 13. PMID 22699907, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
    Title: Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
  2. Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis.
    Title: Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis.
  3. ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion.
    Title: ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion.
  4. Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.
    Title: Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.
  5. A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor.
    Title: A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor.
  6. Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication.
    Title: Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication.
  7. Kidins220 has a prominent role in tumor development by participating in a complex signaling pathways. (Review)
    Title: Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review).
  8. Kidins220 binds to the B cell antigen receptor and regulates B cell development and activation.
    Title: Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
  9. the existence of novel Kidins220/ARMS splice isoforms with unique properties
    Title: Novel Kidins220/ARMS Splice Isoforms: Potential Specific Regulators of Neuronal and Cardiovascular Development.
  10. The scaffold protein Kidins220 associates with brain voltage-gated sodium channels and modulates their activity.
    Title: Functional Interaction between the Scaffold Protein Kidins220/ARMS and Neuronal Voltage-Gated Na+ Channels.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nerve growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinase D-interacting substrate of 220 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081378.2 → NP_001074847.1  kinase D-interacting substrate of 220 kDa isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC159307, CT010478
    Consensus CDS
    CCDS36424.1
    UniProtKB/TrEMBL
    E9Q9B7
    Related
    ENSMUSP00000063999.6, ENSMUST00000066652.7
    Conserved Domains (5) summary
    PHA02736
    Location:348 → 412
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 377
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:440 → 953
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  2. NM_001418114.1 → NP_001405043.1  kinase D-interacting substrate of 220 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159307, CT010478

  3. NM_001418115.1 → NP_001405044.1  kinase D-interacting substrate of 220 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159307, CT010478
    Related
    ENSMUSP00000152726.2, ENSMUST00000220459.2

  4. NM_001418116.1 → NP_001405045.1  kinase D-interacting substrate of 220 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159307, CT010478

  5. NM_001418117.1 → NP_001405046.1  kinase D-interacting substrate of 220 kDa isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159307, CT010478

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    25024909..25113151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515259.4 → XP_006515322.1  kinase D-interacting substrate of 220 kDa isoform X11

    Conserved Domains (5) summary
    PHA02736
    Location:349 → 413
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 378
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:441 → 954
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  2. XM_006515260.5 → XP_006515323.1  kinase D-interacting substrate of 220 kDa isoform X12

    Related
    ENSMUSP00000152399.2, ENSMUST00000222013.2
    Conserved Domains (5) summary
    PHA02736
    Location:349 → 413
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 378
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:441 → 954
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  3. XM_017315243.3 → XP_017170732.1  kinase D-interacting substrate of 220 kDa isoform X13

    Conserved Domains (5) summary
    PHA02736
    Location:349 → 413
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 378
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:441 → 954
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  4. XM_017315244.3 → XP_017170733.1  kinase D-interacting substrate of 220 kDa isoform X14

    Conserved Domains (5) summary
    PHA02736
    Location:349 → 413
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 378
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:441 → 954
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  5. XM_006515250.5 → XP_006515313.1  kinase D-interacting substrate of 220 kDa isoform X1

    See identical proteins and their annotated locations for XP_006515313.1

    Conserved Domains (5) summary
    PHA02736
    Location:349 → 413
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 378
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:441 → 954
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  6. XM_030246980.2 → XP_030102840.1  kinase D-interacting substrate of 220 kDa isoform X2

    UniProtKB/TrEMBL
    E9Q9B7
    Conserved Domains (5) summary
    PHA02736
    Location:348 → 412
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 377
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:440 → 953
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  7. XM_006515251.5 → XP_006515314.1  kinase D-interacting substrate of 220 kDa isoform X1

    See identical proteins and their annotated locations for XP_006515314.1

    Conserved Domains (5) summary
    PHA02736
    Location:349 → 413
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 378
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:441 → 954
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  8. XM_036157660.1 → XP_036013553.1  kinase D-interacting substrate of 220 kDa isoform X3

    Conserved Domains (5) summary
    PHA02736
    Location:349 → 413
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 378
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:441 → 954
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  9. XM_036157663.1 → XP_036013556.1  kinase D-interacting substrate of 220 kDa isoform X8

    Conserved Domains (5) summary
    PHA02736
    Location:349 → 413
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 378
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:441 → 954
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  10. XM_036157661.1 → XP_036013554.1  kinase D-interacting substrate of 220 kDa isoform X4

    Conserved Domains (5) summary
    PHA02736
    Location:348 → 412
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 377
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:440 → 953
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

  11. XM_006515254.5 → XP_006515317.1  kinase D-interacting substrate of 220 kDa isoform X5

    UniProtKB/TrEMBL
    A0A1Y7VME9
    Related
    ENSMUSP00000152683.2, ENSMUST00000222941.2
    Conserved Domains (5) summary
    PHA02736
    Location:348 → 412
    PHA02736; Viral ankyrin protein; Provisional
    PHA02874
    Location:49 → 377
    PHA02874; ankyrin repeat protein; Provisional
    pfam07693
    Location:440 → 953
    KAP_NTPase; KAP family P-loop domain
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:13 → 58
    Ank_4; Ankyrin repeats (many copies)

RNA

  1. XR_004937557.1 RNA Sequence

  2. XR_004937558.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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