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FGR FGR proto-oncogene, Src family tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 777583, updated on 17-Aug-2024

Summary

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Symbol
FGRprovided by CGNC
Full Name
FGR proto-oncogene, Src family tyrosine kinaseprovided by CGNC
Primary source
CGNC:59070
See related
Ensembl:ENSGALG00010016861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
YRK
Orthologs
human mouse all
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Genomic context

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See FGR in Genome Data Viewer
Location:
chromosome: 23
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 23 NC_052554.1 (2419314..2428327, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 23 NC_052595.1 (2188058..2197093, complement)

Chromosome 23 - NC_052554.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112530200 Neighboring gene WAS protein family member 2 Neighboring gene AT-hook DNA binding motif containing 1 Neighboring gene uncharacterized LOC121107501 Neighboring gene digestive cysteine proteinase 2-like Neighboring gene digestive cysteine proteinase 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues. Sudol M, et al. Oncogene, 1993 Apr. PMID 8455940
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene tyrosine-protein kinase Yrk
Names
p60-Yrk
yes-related kinase
NP_001103257.1
NP_001384266.1
NP_001384267.1
XP_046759531.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109787.2 → NP_001103257.1  proto-oncogene tyrosine-protein kinase Yrk isoform 1

    See identical proteins and their annotated locations for NP_001103257.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000339
    UniProtKB/Swiss-Prot
    Q02977
    Related
    ENSGALP00010023644.1, ENSGALT00010040679.1
    Conserved Domains (4) summary
    cd10418
    Location:144 → 244
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:84 → 139
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd14203
    Location:274 → 521
    PTKc_Src_Fyn_like; Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases
    pfam07714
    Location:270 → 519
    Pkinase_Tyr; Protein tyrosine kinase

  2. NM_001397337.1 → NP_001384266.1  proto-oncogene tyrosine-protein kinase Yrk isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000339
    UniProtKB/TrEMBL
    A0A1D5P353
    Related
    ENSGALP00010023638.1, ENSGALT00010040673.1
    Conserved Domains (3) summary
    cd10367
    Location:144 → 244
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cd12006
    Location:84 → 139
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd14203
    Location:271 → 518
    PTKc_Src_Fyn_like; Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases

  3. NM_001397338.1 → NP_001384267.1  proto-oncogene tyrosine-protein kinase Yrk isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000339
    Conserved Domains (3) summary
    cd12006
    Location:84 → 139
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cl15255
    Location:144 → 231
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:230 → 466
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2419314..2428327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046903575.1 → XP_046759531.1  proto-oncogene tyrosine-protein kinase Yrk isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052595.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2188058..2197093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02977.2 GenPept UniProtKB/Swiss-Prot:Q02977

Gene LinkOut

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