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ZYX zyxin [ Homo sapiens (human) ]

Gene ID: 7791, updated on 27-Nov-2024

Summary

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Official Symbol
ZYXprovided by HGNC
Official Full Name
zyxinprovided by HGNC
Primary source
HGNC:HGNC:13200
See related
Ensembl:ENSG00000159840 MIM:602002; AllianceGenome:HGNC:13200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESP-2; HED-2
Summary
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 122.6), lung (RPKM 100.3) and 25 other tissues See more
Orthologs
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Genomic context

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See ZYX in Genome Data Viewer
Location:
7q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143381345..143391111)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144736772..144746538)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143078438..143088204)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene FAM131B antisense RNA 1 Neighboring gene family with sequence similarity 131 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26792 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143077234-143078134 Neighboring gene FAM131B antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143088659-143089259 Neighboring gene Sharpr-MPRA regulatory region 10434 Neighboring gene microRNA 6892 Neighboring gene Sharpr-MPRA regulatory region 2529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143101922-143102436 Neighboring gene EPH receptor A1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143106021-143106633 Neighboring gene EPHA1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12322 Neighboring gene taste 2 receptor member 62 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene encoding a human testis Sertoli cell component related to LIM domain protein. Yang JX, et al. Biochem Mol Biol Int, 1998 Sep. PMID 9784834
  2. A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions. Gregory Call S, et al. Biochem Biophys Res Commun, 2011 Nov 25. PMID 22056563
  3. Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes. van der Gaag EJ, et al. J Invest Dermatol, 2002 Feb. PMID 11841540
  4. Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells. Ghosh S, et al. J Am Heart Assoc, 2015 Jun 12. PMID 26071033, Free PMC Article
  5. Matrix density alters zyxin phosphorylation, which limits peripheral process formation and extension in endothelial cells invading 3D collagen matrices. Abbey CA, et al. Matrix Biol, 2014 Sep. PMID 25038525

See all (175) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
    Title: Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
  2. Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.
    Title: Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.
  3. Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-beta Signaling Pathways via Integrins.
    Title: Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via Integrins.
  4. Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study.
    Title: Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study.
  5. Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
    Title: Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
  6. Force-responsive Zyxin modulation in periodontal ligament cells is regulated by YAP rather than TAZ.
    Title: Force-responsive Zyxin modulation in periodontal ligament cells is regulated by YAP rather than TAZ.
  7. Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins.
    Title: Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins.
  8. Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival.
    Title: Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival.
  9. Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
    Title: Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
  10. Zyxin promotes MAVS-mediated IFNB1 promoter activation.
    Title: Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zyxin (ZYX) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein zyxin. HIV-1 Nef co-localizes with zyxin in the cortical regions of human podocyte PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell-matrix adhesion IC
Inferred by Curator
more info
 PubMed 
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zyxin
Names
zyxin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010972.2 → NP_001010972.1  zyxin isoform 1

    See identical proteins and their annotated locations for NP_001010972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC008743, BC009360, BU844538
    Consensus CDS
    CCDS5883.1
    UniProtKB/Swiss-Prot
    A4D2G6, B4DQX7, Q15942, Q6I9S4
    UniProtKB/TrEMBL
    H0Y2Y8
    Conserved Domains (3) summary
    cd09349
    Location:351 → 437
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:504 → 570
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:444 → 503
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001362783.2 → NP_001349712.1  zyxin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK298925, BC008743, BM857080
    UniProtKB/TrEMBL
    H0Y2Y8
    Conserved Domains (3) summary
    cd09435
    Location:473 → 539
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:320 → 406
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl25764
    Location:170 → 334
    PAT1; Topoisomerase II-associated protein PAT1

  3. NM_003461.5 → NP_003452.1  zyxin isoform 1

    See identical proteins and their annotated locations for NP_003452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC008743
    Consensus CDS
    CCDS5883.1
    UniProtKB/Swiss-Prot
    A4D2G6, B4DQX7, Q15942, Q6I9S4
    UniProtKB/TrEMBL
    H0Y2Y8
    Related
    ENSP00000324422.5, ENST00000322764.10
    Conserved Domains (3) summary
    cd09349
    Location:351 → 437
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:504 → 570
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:444 → 503
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    143381345..143391111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420817.1 → XP_047276773.1  zyxin isoform X1

    Related
    ENSP00000346417.4, ENST00000354434.8

  2. XM_047420818.1 → XP_047276774.1  zyxin isoform X2

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654714.1 Reference GRCh38.p14 PATCHES

    Range
    709..10475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332171.1 → XP_054188146.1  zyxin isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    144736772..144746538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358968.1 → XP_054214943.1  zyxin isoform X1

  2. XM_054358969.1 → XP_054214944.1  zyxin isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15942.1 GenPept UniProtKB/Swiss-Prot:Q15942

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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