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Yipf6 Yip1 domain family, member 6 [ Mus musculus (house mouse) ]

Gene ID: 77929, updated on 27-Nov-2024

Summary

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Official Symbol
Yipf6provided by MGI
Official Full Name
Yip1 domain family, member 6provided by MGI
Primary source
MGI:MGI:1925179
See related
Ensembl:ENSMUSG00000047694 AllianceGenome:MGI:1925179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A430107J06Rik
Summary
Enables identical protein binding activity. Acts upstream of or within intestinal epithelial cell development. Located in COPII-coated ER to Golgi transport vesicle; cis-Golgi network; and trans-Golgi network. Orthologous to human YIPF6 (Yip1 domain family member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 7.2), placenta adult (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Yipf6 in Genome Data Viewer
Location:
X C3; X 43.19 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (97979922..97992627)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (98936316..98949021)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene oligophrenin 1 Neighboring gene predicted gene, 26000 Neighboring gene predicted gene, 57678 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene predicted gene, 52477

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Wang L, et al. Proc Natl Acad Sci U S A, 2019 Jul 23. PMID 31289229, Free PMC Article
  2. Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice. Brandl K, et al. Proc Natl Acad Sci U S A, 2012 Jul 31. PMID 22802641, Free PMC Article
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity in mice.
    Title: YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
  2. a tissue- and organ-specific function for Yipf6 in the maintenance of intestinal homeostasis and implicate the orthologous human gene as a disease susceptibility locus.
    Title: Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC59484

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intestinal epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi medial cisterna ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi trans cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi trans cisterna ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein YIPF6
Names
YIP1 family member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207633.2 → NP_997516.1  protein YIPF6

    See identical proteins and their annotated locations for NP_997516.1

    Status: VALIDATED

    Source sequence(s)
    AK030473, AL672103, BB642656
    Consensus CDS
    CCDS30296.1
    UniProtKB/Swiss-Prot
    Q8BR70, Q8C531
    UniProtKB/TrEMBL
    B1AV66
    Related
    ENSMUSP00000056039.6, ENSMUST00000054697.7
    Conserved Domains (1) summary
    cl21557
    Location:2 → 232
    Yip1; Yip1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    97979922..97992627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528337.3 → XP_006528400.1  protein YIPF6 isoform X1

    Conserved Domains (1) summary
    cl21557
    Location:19 → 249
    Yip1; Yip1 domain

  2. XM_006528338.5 → XP_006528401.3  protein YIPF6 isoform X2

    UniProtKB/Swiss-Prot
    Q8BR70, Q8C531
    UniProtKB/TrEMBL
    B1AV66
    Conserved Domains (1) summary
    cl21557
    Location:2 → 232
    Yip1; Yip1 domain

  3. XM_006528339.5 → XP_006528402.3  protein YIPF6 isoform X2

    UniProtKB/Swiss-Prot
    Q8BR70, Q8C531
    UniProtKB/TrEMBL
    B1AV66
    Related
    ENSMUSP00000117981.2, ENSMUST00000151353.8
    Conserved Domains (1) summary
    cl21557
    Location:2 → 232
    Yip1; Yip1 domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030007.1: Suppressed sequence

    Description
    NM_030007.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BR70.1 GenPept UniProtKB/Swiss-Prot:Q8BR70

Gene LinkOut

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Chemical Information
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