U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmem190 transmembrane protein 190 [ Mus musculus (house mouse) ]

Gene ID: 78052, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Tmem190provided by MGI
Official Full Name
transmembrane protein 190provided by MGI
Primary source
MGI:MGI:1925302
See related
Ensembl:ENSMUSG00000013091 AllianceGenome:MGI:1925302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930572D21Rik
Summary
Enables identical protein binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in inner acrosomal membrane. Orthologous to human TMEM190 (transmembrane protein 190). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 55.9) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tmem190 in Genome Data Viewer
Location:
7 A1; 7 2.77 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4784788..4787340)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4782549..4784341)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17937 Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene interleukin 11 Neighboring gene transmembrane protein 238 Neighboring gene STARR-positive B cell enhancer ABC_E6507 Neighboring gene predicted gene, 57780 Neighboring gene ribosomal protein L28

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. Nishimura H, et al. Reproduction, 2011 Apr. PMID 21273369
  2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mouse sperm protein complex(es) including TMEM190 plays an indirect role(s) in sperm-oocyte fusion.
    Title: Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in inner acrosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in inner acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 190

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030028.1 → NP_084304.1  transmembrane protein 190 precursor

    See identical proteins and their annotated locations for NP_084304.1

    Status: VALIDATED

    Source sequence(s)
    AK019807, BU936271, BX631095
    Consensus CDS
    CCDS51976.1
    UniProtKB/Swiss-Prot
    Q9D2E9
    Related
    ENSMUSP00000013235.5, ENSMUST00000013235.6
    Conserved Domains (1) summary
    pfam15431
    Location:22 → 142
    TMEM190; Transmembrane protein 190

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4784788..4787340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153565.1 → XP_036009458.1  transmembrane protein 190 isoform X2

    Conserved Domains (1) summary
    pfam15431
    Location:29 → 154
    TMEM190; Transmembrane protein 190

  2. XM_006540434.4 → XP_006540497.1  transmembrane protein 190 isoform X1

    Conserved Domains (1) summary
    pfam15431
    Location:42 → 167
    TMEM190; Transmembrane protein 190
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2E9.1 GenPept UniProtKB/Swiss-Prot:Q9D2E9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools