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Naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit [ Mus musculus (house mouse) ]

Gene ID: 78689, updated on 4-Jan-2025

Summary

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Official Symbol
Naa35provided by MGI
Official Full Name
N(alpha)-acetyltransferase 35, NatC auxiliary subunitprovided by MGI
Primary source
MGI:MGI:1925939
See related
Ensembl:ENSMUSG00000021555 AllianceGenome:MGI:1925939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mak10; A330021G12Rik; A330027C19Rik; C030004C14Rik
Summary
Involved in smooth muscle cell proliferation. Located in cytoplasm. Is expressed in embryo. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E14 (RPKM 22.3), CNS E11.5 (RPKM 21.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Naa35 in Genome Data Viewer
Location:
13 B2; 13 31.87 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59733147..59782612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59585333..59634798)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_34711 Neighboring gene RIKEN cDNA A230056J06 gene Neighboring gene STARR-seq mESC enhancer starr_34713 Neighboring gene STARR-seq mESC enhancer starr_34715 Neighboring gene STARR-seq mESC enhancer starr_34717 Neighboring gene golgi membrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_34719 Neighboring gene RIKEN cDNA 4921517D22 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
  2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex ISO
Inferred from Sequence Orthology
more info
  
part_of NatC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Names
MAK10 homolog, amino-acid N-acetyltransferase subunit
Nalpha acetyltransferase 35
embryonic growth-associated protein
protein MAK10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384120.1 → NP_001371049.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134869, AC135469
    UniProtKB/Swiss-Prot
    Q05CD3, Q6PHQ8, Q8BYJ9, Q8K3H2
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

  2. NM_001384121.1 → NP_001371050.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134869, AC135469
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

  3. NM_030153.2 → NP_084429.2  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 1

    See identical proteins and their annotated locations for NP_084429.2

    Status: VALIDATED

    Source sequence(s)
    BC056435, BY100294
    Consensus CDS
    CCDS26575.1
    UniProtKB/Swiss-Prot
    Q05CD3, Q6PHQ8, Q8BYJ9, Q8K3H2
    Related
    ENSMUSP00000022038.8, ENSMUST00000022038.15
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RNA

  1. NR_168734.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134869, AC135469

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    59733147..59782612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247467.2 → XP_030103327.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

    Conserved Domains (1) summary
    pfam04112
    Location:189 → 324
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

  2. XM_036158225.1 → XP_036014118.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

    Conserved Domains (1) summary
    pfam04112
    Location:189 → 324
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RNA

  1. XR_004938075.1 RNA Sequence

  2. XR_004938076.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PHQ8.1 GenPept UniProtKB/Swiss-Prot:Q6PHQ8

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