Hspb3 heat shock protein family B (small) member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hspb3provided by RGD
Official Full Name: heat shock protein family B (small) member 3provided by RGD
Primary source: RGD:68345
See related: EnsemblRapid:ENSRNOG00000010992 AllianceGenome:RGD:68345
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be located in nucleus. Predicted to be active in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 4. Orthologous to human HSPB3 (heat shock protein family B (small) member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (47028451..47029165, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (45295285..45295999, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (45517788..45518502, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Despite the high level of sequence homology within the small heat-shock proteins (sHSPs) family the biochemical properties of the HSPB2/B3 complex are distinctly different from those of other sHSPs.
Title: The small heat-shock proteins HSPB2 and HSPB3 form well-defined heterooligomers in a unique 3 to 1 subunit ratio.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: heat shock protein beta-3

Names: heat shock 27kD protein 3; heat shock 27kD protein family, member 3; heat shock 27kDa protein 3; heat shock protein 3; heat shock protein B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031750.1 → NP_113938.1 heat shock protein beta-3

See identical proteins and their annotated locations for NP_113938.1

Status: PROVISIONAL

Source sequence(s)

AF203374

UniProtKB/Swiss-Prot

Q9QZ58

UniProtKB/TrEMBL

A6I5R7, G3V7G6

Related

ENSRNOP00000014627.1, ENSRNOT00000014627.5

Conserved Domains (1) summary

cd06477
Location:65 → 147

ACD_HspB3_Like; Alpha crystallin domain (ACD) found in mammalian HspB3, also known as heat-shock protein 27-like protein (HSPL27, 17-kDa) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are ...