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Fgr FGR proto-oncogene, Src family tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 79113, updated on 4-Jan-2025

Summary

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Official Symbol
Fgrprovided by RGD
Official Full Name
FGR proto-oncogene, Src family tyrosine kinaseprovided by RGD
Primary source
RGD:621319
See related
EnsemblRapid:ENSRNOG00000009912 AllianceGenome:RGD:621319
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p55-Fgr
Summary
Enables protein tyrosine kinase activity. Involved in myoblast proliferation. Predicted to be located in actin cytoskeleton; aggresome; and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 194.9), Lung (RPKM 104.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fgr in Genome Data Viewer
Location:
5q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150473767..150503524)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145189814..145219571)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151172189..151199746)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 76, member A Neighboring gene uncharacterized LOC120102995 Neighboring gene uncharacterized LOC108351145 Neighboring gene AT hook, DNA binding motif, containing 1 Neighboring gene uncharacterized LOC120102997 Neighboring gene WASP family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hierarchical phosphorylation of a 50-kDa protein by protein tyrosine kinases TPK-IIB and C-Fgr, and its identification as HS1 hematopoietic-lineage cell-specific protein. Brunati AM, et al. Eur J Biochem, 1995 Apr 1. PMID 7744027
  2. Specific expression of human c-fgr in natural immunity effector cells. Inoue K, et al. Mol Cell Biol, 1990 Apr. PMID 2181286, Free PMC Article
  3. Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase. Axelsson L, et al. Exp Cell Res, 2000 Apr 10. PMID 10739672
  4. The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation. Shen K, et al. Sci Signal, 2018 Oct 23. PMID 30352950
  5. Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity. Yan SR, et al. FEBS Lett, 1996 Feb 12. PMID 8603737

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation
    Title: The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.
  2. findings provide the first description of a mechanism for activation of phospholipase D2 in a physiological setting and of a role for Fyn and Fgr in Fc epsilon RI-mediated signaling.
    Title: Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables immunoglobulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables immunoglobulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphotyrosine residue binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in myoblast proliferation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mast cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in aggresome IEA
Inferred from Electronic Annotation
more info
  
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Fgr
Names
Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
feline Gardner-Rasheed sarcoma viral oncogene
proto-oncogene c-Fgr
proto-oncogene tyrosine-protein kinase Fgr
NP_077059.2
XP_006239141.1
XP_006239142.1
XP_006239143.1
XP_006239144.1
XP_038966752.1
XP_038966753.1
XP_038966754.1
XP_038966755.1
XP_038966757.1
XP_063144531.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024145.3 → NP_077059.2  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_077059.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Related
    ENSRNOP00000013779.3, ENSRNOT00000013778.7
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    150473767..150503524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239080.5 → XP_006239142.1  tyrosine-protein kinase Fgr isoform X1

    See identical proteins and their annotated locations for XP_006239142.1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039110826.2 → XP_038966754.1  tyrosine-protein kinase Fgr isoform X1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006239081.5 → XP_006239143.1  tyrosine-protein kinase Fgr isoform X1

    See identical proteins and their annotated locations for XP_006239143.1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Related
    ENSRNOP00000108194.1, ENSRNOT00000126557.1
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006239082.5 → XP_006239144.1  tyrosine-protein kinase Fgr isoform X1

    See identical proteins and their annotated locations for XP_006239144.1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  5. XM_039110829.2 → XP_038966757.1  tyrosine-protein kinase Fgr isoform X1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  6. XM_039110825.2 → XP_038966753.1  tyrosine-protein kinase Fgr isoform X1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  7. XM_039110824.2 → XP_038966752.1  tyrosine-protein kinase Fgr isoform X1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  8. XM_006239079.5 → XP_006239141.1  tyrosine-protein kinase Fgr isoform X1

    See identical proteins and their annotated locations for XP_006239141.1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  9. XM_039110827.2 → XP_038966755.1  tyrosine-protein kinase Fgr isoform X1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Conserved Domains (3) summary
    cd10367
    Location:128 → 228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68 → 125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255 → 502
    PKc_like; Protein Kinases, catalytic domain

  10. XM_063288461.1 → XP_063144531.1  tyrosine-protein kinase Fgr isoform X1

    UniProtKB/Swiss-Prot
    Q63206, Q6P6U0
    Related
    ENSRNOP00000101725.1, ENSRNOT00000127646.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6U0.1 GenPept UniProtKB/Swiss-Prot:Q6P6U0

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