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Arf2 ADP-ribosylation factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79119, updated on 27-Nov-2024

Summary

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Official Symbol
Arf2provided by RGD
Official Full Name
ADP-ribosylation factor 2provided by RGD
Primary source
RGD:621271
See related
EnsemblRapid:ENSRNOG00000004807 AllianceGenome:RGD:621271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARL17A (ADP ribosylation factor like GTPase 17A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 108.4), Adrenal (RPKM 106.6) and 9 other tissues See more
Orthologs
mouse all
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Genomic context

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See Arf2 in Genome Data Viewer
Location:
10q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89367843..89389644)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88867836..88889654)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (92018562..92040335)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene N-ethylmaleimide sensitive factor, vesicle fusing ATPase Neighboring gene uncharacterized LOC134480720 Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene signal peptide peptidase like 2C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities. Price SR, et al. Mol Cell Biochem, 1996 Jun 7. PMID 8813705
  2. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). Hosaka M, et al. J Biochem, 1996 Oct. PMID 8947846
  3. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Sinsky J, et al. J Proteome Res, 2020 Jun 5. PMID 32357304
  4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
  5. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC114313

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor 2
NP_077064.1
XP_038942837.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024150.3 → NP_077064.1  ADP-ribosylation factor 2

    See identical proteins and their annotated locations for NP_077064.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P84082, Q4KM00
    UniProtKB/TrEMBL
    A0A8I5ZKF2, A6HJT6
    Related
    ENSRNOP00000077987.1, ENSRNOT00000113470.2
    Conserved Domains (1) summary
    cl40481
    Location:1 → 180
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    89367843..89389644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086909.2 → XP_038942837.1  ADP-ribosylation factor 2 isoform X1

    UniProtKB/Swiss-Prot
    P84082, Q4KM00
    UniProtKB/TrEMBL
    A0A8I5ZKF2, A6HJT6
    Related
    ENSRNOP00000006483.4, ENSRNOT00000006483.7
    Conserved Domains (1) summary
    cl40481
    Location:1 → 180
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84082.1 GenPept UniProtKB/Swiss-Prot:P84082

Gene LinkOut

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