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snai1b snail family zinc finger 1b [ Danio rerio (zebrafish) ]

Gene ID: 792194, updated on 2-Nov-2024

Summary

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Official Symbol
snai1bprovided by ZNC
Official Full Name
snail family zinc finger 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-514
See related
Ensembl:ENSDARG00000046019 AllianceGenome:ZFIN:ZDB-GENE-980526-514
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sna2; snail2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle progenitor cell migration to the midline involved in heart field formation; mesodermal cell migration; and posterior lateral line neuromast primordium migration. Is expressed in several structures, including ectoderm; heart; mesoderm; neural crest; and trunk. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See snai1b in Genome Data Viewer
Location:
chromosome: 23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (2502228..2513415, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (2567181..2573868, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene inactive serine protease 35 Neighboring gene zinc finger protein 420 Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene gamma-glutamyltransferase 7 Neighboring gene protein diaphanous homolog 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cardiac neural crest contributes to cardiomyogenesis in zebrafish. Sato M, et al. Dev Biol, 2003 May 1. PMID 12710962
  2. Early induction of neural crest cells: lessons learned from frog, fish and chick. Aybar MJ, et al. Curr Opin Genet Dev, 2002 Aug. PMID 12100892
  3. Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Thisse C, et al. Dev Biol, 1994 Aug. PMID 8045345
  4. Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning. Léger S, et al. Mech Dev, 2002 Nov. PMID 12385757
  5. Equivalence in the genetic control of hindbrain segmentation in fish and mouse. Moens CB, et al. Development, 1998 Feb. PMID 9425134

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression.
    Title: The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression.
  2. snail1b expression is initiated by chemokines first encountered by leading primordium cells and its expression plays a crucial role in initiating collective migration of the posterior lateral line primordium.
    Title: Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.
  3. The results provide the molecular mechanism how snai1b controls the morphogenesis of heart during embryonic development
    Title: Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos.
  4. Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication
    Title: Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.
  5. Snail genes not only act as inducers of epithelial-to-mesenchymal transition, but also as more general regulators of cell adhesion and movement.
    Title: Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle progenitor cell migration to the midline involved in heart field formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardioblast migration to the midline involved in heart field formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within posterior lateral line neuromast primordium migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within posterior lateral line neuromast primordium migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
snail family zinc finger 1b
Names
snail homolog 1b
snail-2
snail1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130989.3 → NP_571064.2  snail family zinc finger 1b

    See identical proteins and their annotated locations for NP_571064.2

    Status: PROVISIONAL

    Source sequence(s)
    BC162632
    UniProtKB/TrEMBL
    A0A8M9PT75, B3DH44
    Related
    ENSDARP00000067651.1, ENSDART00000067652.4
    Conserved Domains (3) summary
    sd00017
    Location:175 → 195
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:201 → 223
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:188 → 211
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    2502228..2513415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216807.1 → XP_068072908.1  snail family zinc finger 1b isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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