bgnb biglycan b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bgnbprovided by ZNC
Official Full Name: biglycan bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-21
See related: Ensembl:ENSDARG00000002945 AllianceGenome:ZFIN:ZDB-GENE-040426-21
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bgn; zgc:77123
Summary: Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alar plate midbrain region; central nervous system; neurons; pectoral fin; and pectoral fin bud. Human ortholog(s) of this gene implicated in Meester-Loeys syndrome and X-linked spondyloepimetaphyseal dysplasia. Orthologous to human BGN (biglycan). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (20014030..20051335, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (20087687..20124992, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: biglycan b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001825.2 → NP_001001825.2 biglycan b precursor

Status: VALIDATED

Source sequence(s)

AL953864, BX323050

UniProtKB/TrEMBL

A0A8M1MZN9, B7ZDB5

Related

ENSDARP00000049835.7, ENSDART00000049836.9

Conserved Domains (5) summary

smart00013
Location:68 → 100

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:138 → 329

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:77 → 97

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:99 → 137

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:101 → 156

LRR_8; Leucine rich repeat