U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rab6a RAB6A, member RAS oncogene family [ Danio rerio (zebrafish) ]

Gene ID: 793785, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
rab6aprovided by ZNC
Official Full Name
RAB6A, member RAS oncogene familyprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2849
See related
Ensembl:ENSDARG00000103714 AllianceGenome:ZFIN:ZDB-GENE-040426-2849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb43c01; zgc:55788; wu:fb43c01
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in vesicle-mediated transport. Orthologous to human RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rab6a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (36695597..36711701)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (36751839..36767943)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene serine/threonine-protein kinase pim-3 Neighboring gene si:ch211-176g13.8 Neighboring gene pleckstrin homology domain containing B1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization. Fogerty J, et al. Adv Exp Med Biol, 2016. PMID 26427413, Free PMC Article
  2. In vivo imaging of molecular interactions at damaged sarcolemma. Roostalu U, et al. Dev Cell, 2012 Mar 13. PMID 22421042
  3. Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Huang L, et al. Sci Rep, 2019 Feb 12. PMID 30755680, Free PMC Article
  4. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617
  5. A plasmid library of full-length zebrafish rab proteins for in vivo cell biology. Hall TE, et al. Cell Logist, 2017. PMID 28396820, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that basal body docking was unaffected in dynein 1 (dync1h1) mutation, but rab GTP-binding protein Rab6 expression was reduced.
    Title: Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC55788

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ras-related protein Rab-6A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328529.1 → NP_001315458.1  ras-related protein Rab-6A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). Variants 1 and 2 encode isoforms (1 and 2, respectively) of the same length that differ in their amino acid sequence.
    Source sequence(s)
    AL845435, CU694807
    UniProtKB/TrEMBL
    A0A8M2BDC5, A0A8M3BD98, A9ULS4
    Related
    ENSDARP00000130990.1, ENSDART00000169015.2
    Conserved Domains (2) summary
    smart00175
    Location:14 → 171
    RAB; Rab subfamily of small GTPases
    cd01861
    Location:14 → 174
    Rab6; Rab GTPase family 6 (Rab6)

  2. NM_001328530.1 → NP_001315459.1  ras-related protein Rab-6A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. Variants 1 and 2 encode isoforms (1 and 2, respectively) of the same length that differ in their amino acid sequence.
    Source sequence(s)
    AL845435, CU694807, EH453941
    UniProtKB/TrEMBL
    A0A0R4IH39, A0A8M1P3Z5
    Related
    ENSDARP00000134740.1, ENSDART00000171392.2
    Conserved Domains (2) summary
    smart00175
    Location:14 → 171
    RAB; Rab subfamily of small GTPases
    cd01861
    Location:14 → 174
    Rab6; Rab GTPase family 6 (Rab6)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    36695597..36711701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223829.1 → XP_068079930.1  ras-related protein Rab-6A isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDC5, A0A8M3BD98, A9ULS4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_214765.1: Suppressed sequence

    Description
    NM_214765.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.