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OGFRL1 opioid growth factor receptor like 1 [ Homo sapiens (human) ]

Gene ID: 79627, updated on 27-Nov-2024

Summary

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Official Symbol
OGFRL1provided by HGNC
Official Full Name
opioid growth factor receptor like 1provided by HGNC
Primary source
HGNC:HGNC:21378
See related
Ensembl:ENSG00000119900 AllianceGenome:HGNC:21378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ331H24.1
Summary
Predicted to enable opioid growth factor receptor activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 22.5), esophagus (RPKM 15.1) and 24 other tissues See more
Orthologs
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Genomic context

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See OGFRL1 in Genome Data Viewer
Location:
6q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (71288811..71309059)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (72469249..72489496)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (71998514..72018762)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901338 Neighboring gene uncharacterized LOC124901339 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:71961178-71961445 Neighboring gene coiled-coil domain containing 112 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17326 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:72077050-72078249 Neighboring gene origin of replication 343 Neighboring gene microRNA 30c-2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:72111792-72112320 Neighboring gene microRNA 30a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1, as causative of autosomal recessive retinitis pigmentosa. Abd El-Aziz MM, et al. Ophthalmic Res, 2006. PMID 16192744
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21079, MGC102783

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables opioid growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
opioid growth factor receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324266.2 → NP_001311195.1  opioid growth factor receptor-like protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI800853, AK124833, AK308623, AL137346, BC018688, BX379107, BX420584, BX488500, CK819012, DA151056, DA330565, DA852679
    UniProtKB/Swiss-Prot
    Q5TC84
    Conserved Domains (2) summary
    pfam04664
    Location:114 → 320
    OGFr_N; Opioid growth factor receptor (OGFr) conserved region
    cl15483
    Location:254 → 434
    Hid1; High-temperature-induced dauer-formation protein

  2. NM_024576.5 → NP_078852.3  opioid growth factor receptor-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_078852.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AI800853, AK124833, AK308623, AL137346, BC018688, BX488500, CK819012, DA151056, DA330565, DA852679
    Consensus CDS
    CCDS34482.1
    UniProtKB/Swiss-Prot
    Q2TAC1, Q5TC84, Q8NEQ4, Q9H7B5
    Related
    ENSP00000359464.3, ENST00000370435.5
    Conserved Domains (2) summary
    pfam04664
    Location:113 → 319
    OGFr_N; Opioid growth factor receptor (OGFr) conserved region
    cl15483
    Location:253 → 433
    Hid1; High-temperature-induced dauer-formation protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    71288811..71309059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419365.1 → XP_047275321.1  opioid growth factor receptor-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRI0
    Related
    ENSP00000496790.1, ENST00000650315.1

  2. XM_017011305.3 → XP_016866794.1  opioid growth factor receptor-like protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    72469249..72489496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356435.1 → XP_054212410.1  opioid growth factor receptor-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRI0

  2. XM_054356431.1 → XP_054212406.1  opioid growth factor receptor-like protein 1 isoform X1

  3. XM_054356436.1 → XP_054212411.1  opioid growth factor receptor-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRI0

  4. XM_054356432.1 → XP_054212407.1  opioid growth factor receptor-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRI0

  5. XM_054356433.1 → XP_054212408.1  opioid growth factor receptor-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRI0

  6. XM_054356434.1 → XP_054212409.1  opioid growth factor receptor-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRI0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TC84.1 GenPept UniProtKB/Swiss-Prot:Q5TC84

Gene LinkOut

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