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cert1a ceramide transporter 1a [ Danio rerio (zebrafish) ]

Gene ID: 796455, updated on 4-Jan-2025

Summary

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Official Symbol
cert1aprovided by ZNC
Official Full Name
ceramide transporter 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080724-10
See related
Ensembl:ENSDARG00000024325 AllianceGenome:ZFIN:ZDB-GENE-080724-10
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cert1; col4a3bp; col4a3bpa; zgc:92147; wu:fc37f11
Summary
Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane lipid transfer. Predicted to act upstream of or within lipid transport and muscle organ development. Predicted to be located in Golgi apparatus. Predicted to be active in cytosol. Is expressed in immature eye. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 34. Orthologous to human CERT1 (ceramide transporter 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See cert1a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (50913300..50967971)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (50266707..50321378)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene nucleolar protein 6 (RNA-associated) Neighboring gene arylsulfatase family, member K Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase a Neighboring gene uncharacterized LOC137495632

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development. Granero-Moltó F, et al. J Biol Chem, 2008 Jul 18. PMID 18424781, Free PMC Article
  2. Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair. Simões FC, et al. Nat Commun, 2020 Jan 30. PMID 32001677, Free PMC Article
  3. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
  4. Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. Casey MA, et al. G3 (Bethesda), 2022 Mar 4. PMID 35079792, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study found both GPBP isoforms are expressed during early development &, when depleted, lead to apoptosis; results suggest GPBP is an important factor for normal skeletal muscle & brain development
    Title: Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ceramide 1-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide 1-phosphate transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ceramide transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ER to Golgi ceramide transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermembrane lipid transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ceramide transfer protein
Names
WITHDRAWN:zgc:92147
cert
collagen type IV alpha-3-binding protein
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
goodpasture antigen-binding protein
NP_001017914.3
NP_001268801.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017914.4 → NP_001017914.3  ceramide transfer protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BX000437
    UniProtKB/Swiss-Prot
    A2BGX3, A2BGX4, B4XAM8, B4XAM9, Q5M7Y0
    UniProtKB/TrEMBL
    A0A8M1N5P3, F8W2V5
    Related
    ENSDARP00000124594.1, ENSDART00000149787.3
    Conserved Domains (2) summary
    cd08872
    Location:387 → 620
    START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
    cd13283
    Location:23 → 122
    PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain

  2. NM_001281872.1 → NP_001268801.1  ceramide transfer protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BX000437
    UniProtKB/Swiss-Prot
    A2BGX3, A2BGX4, B4XAM8, B4XAM9, Q5M7Y0
    UniProtKB/TrEMBL
    A0A2R9YJF5, A0A8M1P0R7
    Related
    ENSDARP00000153901.1, ENSDART00000190837.1
    Conserved Domains (2) summary
    cd08872
    Location:360 → 594
    START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
    cd13283
    Location:23 → 122
    PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    50913300..50967971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394610.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    43526..97594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001100960.1: Suppressed sequence

    Description
    NM_001100960.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M7Y0.2 GenPept UniProtKB/Swiss-Prot:Q5M7Y0

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