abcb5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcb5provided by ZNC
Official Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6414
See related: Ensembl:ENSDARG00000021787 AllianceGenome:ZFIN:ZDB-GENE-030131-6414
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mdr1; im:7158730; wu:fc18f02; wu:fi81f06
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Acts upstream of or within detoxification of mercury ion. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in several structures, including EVL; integument; liver; periderm; and pleuroperitoneal region. Orthologous to human ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (19540575..19568387, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (19734697..19762858, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter.
Title: Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter.
similar pattern of mRNA expression of Pregnane X Receptor (PXR), cytochrome P4503A and MDR1 genes found in fish treated with different PXR inducers suggests that the intrinsic association between these three genes is conserved in zebrafish
Title: Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish.

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General gene information

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Markers

fc18f02.x1 (e-PCR)
- UniSTS:192880

fc18f02.x1 (e-PCR)
- UniSTS:192881

fi81f06.x1 (e-PCR)
- UniSTS:198066

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within detoxification of mercury ion	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-binding cassette, sub-family B (MDR/TAP), member 5; ATP-dependent translocase ABCB1

Names: ABC efflux transporter 5; abcb1a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

19540575..19568387 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001922682.8 → XP_001922717.3 ATP-dependent translocase ABCB1

See identical proteins and their annotated locations for XP_001922717.3

UniProtKB/TrEMBL

F1R7A8, K9M7N8

Related

ENSDARP00000121883.1, ENSDART00000141616.2

Conserved Domains (3) summary

cd03249
Location:438 → 675

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:48 → 1328

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:88 → 389

ABC_membrane; ABC transporter transmembrane region